Unleashing XIST from X-chromosome inactivation.

Autor: Morey C; Epigenetics and Cell Fate, CNRS, Université Paris Cité, Paris, France., Rougeulle C; Epigenetics and Cell Fate, CNRS, Université Paris Cité, Paris, France. Electronic address: claire.rougeulle@u-paris.fr., Ouimette JF; Epigenetics and Cell Fate, CNRS, Université Paris Cité, Paris, France.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2024 Nov 26; Vol. 92, pp. 102446. Date of Electronic Publication: 2024 Nov 26.
DOI: 10.1016/j.ceb.2024.102446
Abstrakt: Recognition that the most abundant class of genes present in the human genome are those producing long noncoding RNA (lncRNA) has hyped research on this category of transcripts. One such prototypical RNA, Xist, has particularly fueled interest. Initially characterized for its specific expression from the inactive X (Xi), recent studies have uncovered the molecular mechanisms underlying its essential role in the initiation of X-chromosome inactivation, from its exquisitely precise transcriptional regulation to the plethora of protein interactors forming the Xist ribonucleoprotein (RNP) that mediate its gene silencing activity. Here, we will discuss the recent advances that have broadened our knowledge of Xist functions, challenging classical models and revealing unsuspected, unconventional actions of its RNP.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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