Generation of the TSHSUi002-A induced pluripotent stem cell line from a patient with Peutz-Jeghers syndrome carring STK11 gene mutation.

Autor:	Chen W; Cheeloo College of Medicine, Shandong University, Jinan, China., Wang H; Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China., Zhu K; Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China., Wang T; Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China., Yu W; Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China., Wu Q; Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, China. Electronic address: 354608721@qq.com.
Jazyk:	angličtina
Zdroj:	Stem cell research [Stem Cell Res] 2024 Dec; Vol. 81, pp. 103618. Date of Electronic Publication: 2024 Nov 22.
DOI:	10.1016/j.scr.2024.103618
Abstrakt:	We report the derivation of an induced pluripotent stem cell (iPSC) line, designated TSHSUi002-A, from a patient with Peutz-Jeghers syndrome carrying a heterozygous c.909C>G mutation in the STK11 gene. The iPSCs were generated through the reprogramming of peripheral blood mononuclear cells using a non-integrating method involving episomal vectors expressing OCT4, SOX2, KLF4, BCL-XL, and c-MYC. These iPSCs exhibit pluripotency markers, are capable of differentiating into cells of all three germ layers in vitro, and maintain a normal karyotype. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier B.V.)
Databáze:	MEDLINE
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