Design of patient-specific mandibular reconstruction plates and a hybrid scaffold.

Autor: Dogan SE; Bogazici University, Institute of Biomedical Engineering, Istanbul, 34684, Turkiye. Electronic address: sait.dogan@std.bogazici.edu.tr., Ozturk C; Bogazici University, Institute of Biomedical Engineering, Istanbul, 34684, Turkiye. Electronic address: cozturk@bogazici.edu.tr., Koc B; 3D Bioprinting Laboratory, Sabanci University Nanotechnology Research and Application Center, Istanbul, 34956, Turkiye; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, 34956, Turkiye. Electronic address: bahattinkoc@sabanciuniv.edu.
Jazyk: angličtina
Zdroj: Computers in biology and medicine [Comput Biol Med] 2024 Nov 26; Vol. 184, pp. 109380. Date of Electronic Publication: 2024 Nov 26.
DOI: 10.1016/j.compbiomed.2024.109380
Abstrakt: Background: Managing segmental mandibular defects remains challenging, requiring a multidisciplinary approach despite the remarkable progress in mandibular reconstruction plates, finite element methods, computer-aided design and manufacturing techniques, and novel surgical procedures. Complex surgeries require a comprehensive approach, as using only reconstruction plates or tissue scaffolds may not be adequate for optimal results. The limitations of the treatment options should be investigated towards a patient-specific trend to provide shorter surgery time, better healing, and lower costs. Integrated hybrid scaffold systems are promising in improving mechanical properties and facilitating healing. By combining different materials and structures, hybrid scaffolds can provide enhanced support and stability to the tissue regeneration process, leading to better patient outcomes. The use of such systems represents a significant advancement in tissue engineering and a wide range of medical procedures.
Materials and Methods: A head and neck computed tomography (CT) data of a patient with odontogenic myxoma was used for creating a three-dimensional (3D) mandible model. Virtual osteotomies were performed to create a segmental defect model, including the angulus mandibulae region. The first mandibular reconstruction plate was designed. Finite elemental analyses (FEA) and topology optimizations were performed to create two different reconstruction plates for different treatment scenarios. The FEA were performed for the resulting two plates to assess their biomechanical performance. To provide osteoconductive and osteoinductive properties a scaffold was designed using the defect area. A biomimetic Tricalcium phosphate-Polycaprolactone (TCP-PCL) hybrid bone scaffold enhanced with Hyaluronic acid dipping was manufactured.
Results: The results of the in-silico analysis indicate that the designed reconstruction plates possess robust biomechanical performance and demonstrate remarkable stability under the most rigorous masticatory activities. Using the Voronoi pattern decreased the mass by %37 without losing endurance. Using reconstruction plates and hybrid scaffolds exhibits promising potential for clinical applications, subject to further in vivo and clinical studies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: