Plasma triacylglycerol length and saturation level mark healthy aging groups in humans.

Autor:	Li W; Amsterdam UMC Location University of Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands.; Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Schomakers BV; Amsterdam UMC Location University of Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands.; Core Facility Metabolomics, Amsterdam UMC Location University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands., van Weeghel M; Amsterdam UMC Location University of Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands.; Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; Core Facility Metabolomics, Amsterdam UMC Location University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands., Grevendonk L; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD, Maastricht, The Netherlands., Vaz FM; Amsterdam UMC Location University of Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands.; Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; Core Facility Metabolomics, Amsterdam UMC Location University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands., Salomons GS; Amsterdam UMC Location University of Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands.; Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; Core Facility Metabolomics, Amsterdam UMC Location University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands., Schrauwen P; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Hoeks J; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD, Maastricht, The Netherlands., Gao AW; Amsterdam UMC Location University of Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands.; Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands., Houtkooper RH; Amsterdam UMC Location University of Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands.; Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands., Janssens GE; Amsterdam UMC Location University of Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands. g.e.janssens@amsterdamumc.nl.; Amsterdam Gastroenterology, Endocrinology and Metabolism Institute, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands. g.e.janssens@amsterdamumc.nl.
Jazyk:	angličtina
Zdroj:	GeroScience [Geroscience] 2024 Nov 27. Date of Electronic Publication: 2024 Nov 27.
DOI:	10.1007/s11357-024-01453-0
Abstrakt:	Complex lipids, essential components in biological processes, exhibit conserved age-related changes that alter membrane properties and cellular functions and are implicated as biomarkers and contributors to longevity and age-related diseases. While physical activity alleviates age-related comorbidities and physical impairments, comprehensive exploration of the underlying biological mechanisms, particularly at the level of complex lipids, remains limited. However, clinical studies suggest that physical activity may counteract these age-related lipidomic changes, presenting a promising avenue for intervention. We performed lipidomic profiling of plasma from an extensively characterized cohort of young and aged individuals. Annotating 1446 unique lipid species across 24 lipid classes, we found the most prominent difference in older adults was an accumulation of triacylglycerols (TGs), with lower physical activity levels associated with higher TG levels in plasma and reduced physical functionality. Remarkably, lipid species in the TG class did not accumulate uniformly. Rather, our study unveiled a negative correlation between higher physical activity levels and TGs with shorter chain lengths and more double bonds in this demographic. Overall, our research highlights that plasma TG length and saturation level can help mark healthy aging groups in humans. These findings deepen our understanding of how aging affects complex lipids and the influence of physical activity on this process. Competing Interests: Declarations. Competing interests: The authors declare no competing interests. (© 2024. The Author(s), under exclusive licence to American Aging Association.)
Databáze:	MEDLINE
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