Ruminative thinking mediates the effects of exposure to adverse life events on psychotic-like experiences.
| Autor: | Fazio L; Department of Medicine and Surgery, Libera Università Mediterranea (LUM) University 'Giuseppe Degennaro', Bari, Italy., Raio A; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy., Banaschewski T; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim, Germany., Bokde ALW; Discipline of Psychiatry, School of Medicine and Trinity College, Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Desrivières S; Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, United Kingdom., Flor H; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany., Garavan H; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, United States., Gowland P; Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom., Grigis A; NeuroSpin Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Université Paris-Saclay, Gif-sur-Yvette, France., Heinz A; Department of Psychiatry and Psychotherapy, CCM Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany., Martinot JL; Institut National de la Santé et de la Recherce Médicale, INSERM U A10 'Trajectoires développementales & psychiatrie', University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France., Paillère Martinot ML; AP-HP. Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France.; Psychiatry Department, EPS Barthélémy Durand, Etampes, France., Artiges E; Institut National de la Santé et de la Recherce Médicale, INSERM U A10 'Trajectoires développementales & psychiatrie', University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.; Psychiatry Department, EPS Barthélémy Durand, Etampes, France., Nees F; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim, Germany.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany., Papadopoulos Orfanos D; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany., Paus T; Department of Psychiatry and Neuroscience, Faculty of Medicine, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada., Poustka L; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany., Smolka MN; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany., Hohmann S; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim, Germany., Holz N; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim, Germany., Vaidya N; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany., Walter H; Department of Psychiatry and Psychotherapy, CCM Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany., Whelan R; School of Psychology, Global Brain Health Institute, Trinity College, Dublin, Ireland., Schumann G; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China., Bertolino A; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.; Psychiatry Unit, Policlinico di Bari, Bari, Italy., Pergola G; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.; Lieber Institute for Brain Development, John Hopkins Medical Campus, Baltimore, MD, United States.; Department of Psychiatry and Behavioral Science, John Hopkins University, Baltimore, MD, United States., Antonucci LA; Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in psychology [Front Psychol] 2024 Nov 12; Vol. 15, pp. 1434470. Date of Electronic Publication: 2024 Nov 12 (Print Publication: 2024). |
| DOI: | 10.3389/fpsyg.2024.1434470 |
| Abstrakt: | Introduction: A growing literature has shown that exposure to adverse life events during childhood or adolescence is associated with the presence of psychotic-like experiences (PLEs), which is in turn associated with the risk of psychotic outcomes. Ruminative thinking, i.e., the tendency to dwell on particular issues or ideas, may affect the perceived aversiveness and ability to cope with adverse life events. However, the role that rumination plays in the relationship between adverse life events and the presence of PLEs remains unclear. The purpose of this study is to assess the association between adverse life events and PLEs in a longitudinal sample of young adults and adolescents, and to investigate whether this relationship is mediated by ruminative thinking. Methods: We used a longitudinal naturalistic sample of 706 volunteers assessed at ages 18 and 22 years, within the Imagen consortium. Lifetime occurrence of adverse life events (i.e., events perceived as strongly negative by participants) was investigated using the Life Events Questionnaire. The Community Assessment of Psychic Experience (CAPE-42) served to assess the presence of PLEs, while ruminative thinking was investigated through the Ruminative Response Scale. Results: Results showed that both frequency of PLEs and their persistence over time were associated with greater adverse life events exposure ( r = 0.32, p < 0.001 and F Discussion: Overall, our findings confirm that the presence of adverse life events may increase the risk of experiencing PLEs in healthy individuals and suggest that dysfunctional coping strategies, such as ruminative thinking, may be related to psychosis proneness. Results do not disentangle whether individuals with greater risk for psychosis tend to ruminate more or whether rumination exacerbates psychosis risk. Competing Interests: GP received lecture fees from Lundbeck and MEGIN. AB received consulting fees from Biogen and lecture fees from Otsuka, Janssen, and Lundbeck. TB served in an advisory or consultancy role for eye level, Infectopharm, Medice, Neurim Pharmaceuticals, Oberberg GmbH, and Takeda, received conference support or speaker's fee by Janssen, Medice, and Takeda, and received royalties from Hogrefe Kohlhammer CIP Medien Oxford University Press. LP served in an advisory or consultancy role for Roche and Viforpharm and received speaker's fee by Shire and received royalties from Hogrefe Kohlhammer and Schattauer. The present work is unrelated to the above grants and relationships. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. The reviewer GS declared a shared affiliation, with no collaboration, with the authors AR, AB, GP, and LA to the handling editor at the time of the review. (Copyright © 2024 Fazio, Raio, Banaschewski, Bokde, Desrivières, Flor, Garavan, Gowland, Grigis, Heinz, Martinot, Paillère Martinot, Artiges, Nees, Papadopoulos Orfanos, Paus, Poustka, Smolka, Hohmann, Holz, Vaidya, Walter, Whelan, Schumann, Bertolino, Pergola, Antonucci and the IMAGEN Consortium.) |
| Databáze: | MEDLINE |
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