The Leishmania Skin Test Predicts Clinic-Immunologic and Therapeutic Outcomes in Cutaneous Leishmaniasis.

Autor:	Guimarães LH; Immunology Service, University Hospital Professor Edgar Santos, Federal University of Bahia, Salvador 40110-160, Bahia, Brazil.; Health Sciences Center, Santo Antonio de Jesus campus, Federal University of Recôncavo da Bahia, Santo Antônio de Jesus 44574-490, Bahia, Brazil.; National Institute of Science and Technology of Tropical Diseases (INCT-DT), MCTI CNPq, Salvador 40110-160, Bahia, Brazil., Zacarias E; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Bahia, Brazil.; Faculty of Pharmacy, Ondina Campus, Federal University of Bahia, Salvador 40170-115, Bahia, Brazil., Nolasco ST; Immunology Service, University Hospital Professor Edgar Santos, Federal University of Bahia, Salvador 40110-160, Bahia, Brazil., Filho AN; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Bahia, Brazil., Lago J; Immunology Service, University Hospital Professor Edgar Santos, Federal University of Bahia, Salvador 40110-160, Bahia, Brazil., Machado PRL; Immunology Service, University Hospital Professor Edgar Santos, Federal University of Bahia, Salvador 40110-160, Bahia, Brazil.; National Institute of Science and Technology of Tropical Diseases (INCT-DT), MCTI CNPq, Salvador 40110-160, Bahia, Brazil., Oliveira J; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Bahia, Brazil., Carvalho LP; Immunology Service, University Hospital Professor Edgar Santos, Federal University of Bahia, Salvador 40110-160, Bahia, Brazil.; National Institute of Science and Technology of Tropical Diseases (INCT-DT), MCTI CNPq, Salvador 40110-160, Bahia, Brazil.; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Bahia, Brazil., Carvalho A; Immunology Service, University Hospital Professor Edgar Santos, Federal University of Bahia, Salvador 40110-160, Bahia, Brazil.; National Institute of Science and Technology of Tropical Diseases (INCT-DT), MCTI CNPq, Salvador 40110-160, Bahia, Brazil.; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Bahia, Brazil., Carvalho EM; Immunology Service, University Hospital Professor Edgar Santos, Federal University of Bahia, Salvador 40110-160, Bahia, Brazil.; National Institute of Science and Technology of Tropical Diseases (INCT-DT), MCTI CNPq, Salvador 40110-160, Bahia, Brazil.; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Bahia, Brazil., Arruda S; National Institute of Science and Technology of Tropical Diseases (INCT-DT), MCTI CNPq, Salvador 40110-160, Bahia, Brazil.; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Bahia, Brazil.; Department of Life Sciences, School of Medicine, Salvador Campus, State University of Bahia, Salvador 41200-105, Bahia, Brazil.
Jazyk:	angličtina
Zdroj:	Pathogens (Basel, Switzerland) [Pathogens] 2024 Nov 19; Vol. 13 (11). Date of Electronic Publication: 2024 Nov 19.
DOI:	10.3390/pathogens13111018
Abstrakt:	Cutaneous leishmaniasis (CL), caused by Leishmania braziliensis , is closely associated with a severe form of the disease, indicated by a positive Leishmania skin test (LST) that assesses and reflects the presence of immune T cells specific to Leishmania antigens. In this study, we compare the clinical, immunologic, and histopathologic features between Leishmania skin test-positive (LST+) and Leishmania skin test-negative (LST-) in CL. Compared to LST+ patients, LST- patients had larger lesions and had been sicker for longer, presented with more instances of therapeutic failure with meglumine antimonate, (MA) and the healing times were higher than LST+. While granulomas were less frequent and the parasite load was higher in LST-, there were more CD8+ T cells and an enhanced production of Granzyme B in the supernatants of biopsies from LST- subjects. This study shows that in LST-, an impairment in Th1 immune response is associated with a high parasite burden, and the pathology is mediated by CD8+ T cells and the enhanced production of Granzyme B. The abnormalities in the immunologic response in LST- patients lead to a more severe disease with a high rate of failure to therapy.
Databáze:	MEDLINE
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