Cytotoxic Effects of Plant Secondary Metabolites and Naturally Occurring Bioactive Peptides on Breast Cancer Model Systems: Molecular Mechanisms.

Autor:	Zasheva D; Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Tsarigradsko Shosse, 73, 1113 Sofia, Bulgaria., Mladenov P; Agrobioinstitute, Agricultural Academy, bul. 'Dragan Tsankov' 8, 1164 Sofia, Bulgaria., Zapryanova S; Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Tsarigradsko Shosse, 73, 1113 Sofia, Bulgaria., Gospodinova Z; Institute of Plant Physiology and Genetics, Bulgarian Academy of Science, 'Acad. Georgi Bonchev' Str., Bl. 21, 1113 Sofia, Bulgaria., Georgieva M; Institute of Plant Physiology and Genetics, Bulgarian Academy of Science, 'Acad. Georgi Bonchev' Str., Bl. 21, 1113 Sofia, Bulgaria., Alexandar I; Institute of Molecular Biology 'Rumen Tzanev', Bulgarian Academy of Sciences, 'Acad. Georgi Bonchev' Str., Bl. 21, 1113 Sofia, Bulgaria., Velinov V; Institute of Plant Physiology and Genetics, Bulgarian Academy of Science, 'Acad. Georgi Bonchev' Str., Bl. 21, 1113 Sofia, Bulgaria., Djilianov D; Agrobioinstitute, Agricultural Academy, bul. 'Dragan Tsankov' 8, 1164 Sofia, Bulgaria., Moyankova D; Agrobioinstitute, Agricultural Academy, bul. 'Dragan Tsankov' 8, 1164 Sofia, Bulgaria., Simova-Stoilova L; Institute of Plant Physiology and Genetics, Bulgarian Academy of Science, 'Acad. Georgi Bonchev' Str., Bl. 21, 1113 Sofia, Bulgaria.
Jazyk:	angličtina
Zdroj:	Molecules (Basel, Switzerland) [Molecules] 2024 Nov 07; Vol. 29 (22). Date of Electronic Publication: 2024 Nov 07.
DOI:	10.3390/molecules29225275
Abstrakt:	Breast cancer is the second leading cause of death among women, and the number of mortal cases in diagnosed patients is constantly increasing. The search for new plant compounds with antitumor effects is very important because of the side effects of conventional therapy and the development of drug resistance in cancer cells. The use of plant substances in medicine has been well known for centuries, but the exact mechanism of their action is far from being elucidated. The molecular mechanisms of cytotoxicity exerted by secondary metabolites and bioactive peptides of plant origin on breast cancer cell lines are the subject of this review.
Databáze:	MEDLINE
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