| Autor: |
Markousis-Mavrogenis G; University Research Institute of Maternal and Child Health and Precision Medicine and UNESCO Chair in Adolescent Health Care, Medical School, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 11527 Athens, Greece.; Olympic Diagnostic Center, 18537 Piraeus, Greece., Vartela V; Onassis Cardiac Surgery Center, 11527 Athens, Greece., Pepe A; Department of Radiology, Medical Faculty, University of Padua, 35127 Padua, Italy., Sierra-Galan L; American British Cowdray Medical Center, Mexico City 05348, Mexico., Androulakis E; Royal Brompton Hospital, Imaging Centre, Guy's and St Thomas' NHS Foundation Trust, London SW3 6NP, UK., Perazzolo A; Department of Radiology, Medical Faculty, University of Padua, 35127 Padua, Italy., Christidi A; Euromedica MRI Unit, 54124 Thessaloniki, Greece., Belegrinos A; Faculty of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece., Giannakopoulou A; Aghia Sophia Children Hospital, 11527 Athens, Greece., Bonou M; Laikon Hospital, 11527 Athens, Greece., Vrettou AR; Attikon Hospital, 11527 Athens, Greece., Lazarioti F; Olympic Diagnostic Center, 18537 Piraeus, Greece., Skantzos V; Olympic Diagnostic Center, 18537 Piraeus, Greece., Quaia E; Department of Radiology, Medical Faculty, University of Padua, 35127 Padua, Italy., Mohiaddin R; Royal Brompton Hospital, Imaging Centre, Guy's and St Thomas' NHS Foundation Trust, London SW3 6NP, UK.; National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK., Mavrogeni SI; University Research Institute of Maternal and Child Health and Precision Medicine and UNESCO Chair in Adolescent Health Care, Medical School, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 11527 Athens, Greece.; Olympic Diagnostic Center, 18537 Piraeus, Greece.; Onassis Cardiac Surgery Center, 11527 Athens, Greece. |
| Abstrakt: |
Introduction . Post-coronavirus disease-2019 (COVID-19) patients may develop cardiac symptoms. We hypothesized that cardiovascular magnetic resonance (CMR) can assess the background of post-COVID-19 cardiac symptoms using multi-parametric evaluation. We aimed to conduct an investigation of symptomatic patients with post-COVID-19 syndrome using CMR (INSPIRE-CMR). Methods . INSIPRE-CMR is a retrospective multicenter study including 174 patients from five centers referred for CMR due to cardiac symptoms. CMR was performed using 3.0 T/1.5 T system (24%/76%, respectively). Myocardial inflammation was determined by the updated Lake Louise criteria. Results . Further, 174 patients with median age of 40 years (IQR: 26-54), 72 (41%) were women, and 17 (9.7%) had a history of autoimmune disease, muscular dystrophy, or cancer. In total, 149 (86%) patients were late gadolinium enhanced (LGE)-positive with a non-ischemic pattern, and of those evaluated with the updated Lake Louise criteria, 141/145 (97%) had ≥1 pathologic T1 index. Based on the T2-criterion, 62/173 (36%) patients had ≥1 pathologic T2 index. Collectively, 48/145 (33%) patients had both positive T1- and T2-criterion. A positive T2-criterion or a combination of a positive T1- and T2-criterion were significantly more common amongst patients with severe COVID-19 [45 (31%) vs. 17 (65%), p = 0.001 and 32 (27%) vs. 16 (64%), p < 0.001, respectively]. During the one-year evaluation, available for 65/174 patients, shortness of breath, chest pain, and arrhythmia were identified in 7 (4%), 15 (8.6%), and 43 (24.7%), respectively. CMR evaluation, available in a minority of them, showed mildly reduced LVEF, while nat T1 mapping and EVC remained at levels higher than the normal values of the local MRI units. Conclusions . The majority of post-COVID-19 patients with cardiac symptoms presented non-ischemic LGE and abnormalities in T1 and T2-based indices. Multi-parametric CMR reveals important information on post-COVID-19 patients, supporting its role in short/long-term evaluation. |
