| Autor: |
Aleksova A; Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, 34100 Trieste, Italy.; Department of Medical Surgical and Health Sciences, University of Trieste, 34125 Trieste, Italy., Janjusevic M; Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, 34100 Trieste, Italy.; Department of Medical Surgical and Health Sciences, University of Trieste, 34125 Trieste, Italy., Pani B; Department of Medical Surgical and Health Sciences, University of Trieste, 34125 Trieste, Italy., Hiche C; Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, 34100 Trieste, Italy., Chicco A; SC Laboratorio Unico, Ospedale Maggiore, Azienda Sanitaria Universitaria Giuliano Isontina, 34125 Trieste, Italy., Derin A; Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, 34100 Trieste, Italy., Zandonà L; SC Laboratorio Unico, Ospedale Maggiore, Azienda Sanitaria Universitaria Giuliano Isontina, 34125 Trieste, Italy., Stenner E; Department of Diagnostics, Azienda USL Toscana Nordovest, 56121 Livorno, Italy., Beltrame D; Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, 34100 Trieste, Italy., Gabrielli M; Department of Medical Surgical and Health Sciences, University of Trieste, 34125 Trieste, Italy., Lovadina S; Department of General and Thoracic Surgery, Cattinara University Hospital, 34149 Trieste, Italy., Corgosinho FC; Faculty of Nutrition, Federal University of Goias, Goiânia 74605-050, Brazil., D'Errico S; Department of Medical Surgical and Health Sciences, University of Trieste, 34125 Trieste, Italy., Marketou M; Cardiology Department Crete, School of Medicine, Heraklion University General Hospital, University of Crete, 70013 Iraklio, Greece., Zwas DR; Linda Joy Pollin Cardiovascular Wellness Center for Women, Heart Institute, Hadassah University Medical Center, Jerusalem 91120, Israel., Sinagra G; Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, 34100 Trieste, Italy.; Department of Medical Surgical and Health Sciences, University of Trieste, 34125 Trieste, Italy., Fluca AL; Cardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, 34100 Trieste, Italy.; Department of Medical Surgical and Health Sciences, University of Trieste, 34125 Trieste, Italy. |
| Abstrakt: |
Background and Aims: Hypovitaminosis D is involved in the development and progression of atherosclerosis, and it is more prevalent in women. The differential impact of hypovitaminosis D on the severity of coronary artery disease (CAD) between genders remains poorly understood. This study aims to address this literature gap. Methods: A total of 1484 consecutive patients with acute myocardial infarction (AMI) were enrolled in the study. Hypovitaminosis D was defined as vitamin D ≤ 20 ng/mL. CAD was defined as the presence of at least one coronary vessel stenosis > 50%, while severe CAD was defined as left main disease and/or three-vessel disease > 50%. Results: The mean age of the cohort was 66.3 (11.5) years, with a predominance of the male gender (71.8%). Vitamin D values were significantly lower in women than in men (15.7 [8.4-25.4] ng/mL vs. 17.9 [11-24.3] ng/mL, p = 0.01). A higher prevalence of severe CAD was observed in female patients with hypovitaminosis D compared to those without (33% vs. 19%, p < 0.01). This finding was not observed in men. Among women, hypovitaminosis D significantly increased the risk of severe CAD (OR: 1.85, p = 0.01), together with diabetes mellitus (DM) and older age, adjusted for GFR < 60 mL/min/1.73 m 2 , cholesterol and body mass index. Furthermore, women with both hypovitaminosis D and DM had more than three times the risk of severe CAD compared with women who lacked both (OR: 3.56, p = 0.02). Conclusions: In women, hypovitaminosis D increases the risk of severe CAD, and the co-existence of hypovitaminosis D and DM triples the incidence of severe CAD. |
