Copaiba Oleoresin Improves Weight Gain and IL-10 Concentration, with No Impact on Hepatic Histology, in Liver Cirrhosis.

Autor: Taffarel M; NUPADS-Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Silva BSD; NUPADS-Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Paulino AMB; NUPADS-Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Telles LO; NUPADS-Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Mendonça ST; NUPADS-Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Santos CVD; NUPADS-Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Giordani MA; NUPADS-Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Nascimento AF; NUPADS-Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil.; ICS-Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Aguiar DH; ICNHS-Institute of Natural, Human and Social Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Sinhorin VDG; Postgraduate Program in Biotechnology and Biodiversity of the Pro Centro-Oeste Network, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Andrighetti CR; ICS-Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Luvizotto RAM; NUPADS-Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil.; ICS-Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil., Bomfim GF; NUPADS-Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil.; ICS-Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil.
Jazyk: angličtina
Zdroj: Biology [Biology (Basel)] 2024 Oct 23; Vol. 13 (11). Date of Electronic Publication: 2024 Oct 23.
DOI: 10.3390/biology13110853
Abstrakt: Copaifera sp. is a native tree in the Amazon region. Copaiba oleoresin has components such as sesquiterpenes, which have anti-inflammatory and antioxidant potential. Liver cirrhosis is the end stage of liver disease with limited therapeutic options. We aimed to evaluate the effect of copaiba oleoresin supplementation on the liver of animals with thioacetamide (TAA)-induced cirrhosis. For the induction of liver cirrhosis, 100 mg/kg of TAA was administered intraperitoneally twice a week for 8 weeks. A total of 200 mg/kg/day of copaiba oleoresin was administered via gavage for the same period. Copaiba oleoresin supplementation improved cirrhosis-associated cachexia by increasing weight gain and body fat. In addition, copaiba oleoresin attenuated systemic inflammation, as shown by the decrease in the circulating C-reactive protein. In the liver, the copaiba oleoresin decreased carbonyl proteins and increased IL-10 compared with TAA-treated rats. TAA groups demonstrated increased SOD, catalase, GST, and GSH activity in the liver. In conclusion, the supplementation of copaiba oleoresin demonstrated a beneficial systemic effect in alleviating cirrhotic cachexia and antioxidant and anti-inflammatory action in the liver. However, it failed to improve the serological and histological markers of liver damage, which could be associated with the advanced stage of the disease.
Databáze: MEDLINE
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