| Autor: |
Gutiérrez-Fernández J; Department of Microbiology, Virgen de las Nieves University Hospital, 18014 Granada, Spain., Cerezo-Collado L; Departmento de Química Inorgánica, Instituto de Biotecnología, Universidad de Granada. 18071 Granada, Spain., Garcés V; Departmento de Química Inorgánica, Instituto de Biotecnología, Universidad de Granada. 18071 Granada, Spain., Alarcón-Guijo P; Departmento de Química Inorgánica, Instituto de Biotecnología, Universidad de Granada. 18071 Granada, Spain., Delgado-López JM; Departmento de Química Inorgánica, Instituto de Biotecnología, Universidad de Granada. 18071 Granada, Spain., Dominguez-Vera JM; Departmento de Química Inorgánica, Instituto de Biotecnología, Universidad de Granada. 18071 Granada, Spain. |
| Jazyk: |
angličtina |
| Zdroj: |
Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2024 Oct 25; Vol. 13 (11). Date of Electronic Publication: 2024 Oct 25. |
| DOI: |
10.3390/antibiotics13111003 |
| Abstrakt: |
Background: Carbapenems are one of the mainstays of treatment for antibiotic-resistant bacteria (ARB). This has made the rise of carbapenem-resistant bacteria a threat to global health. In fact, the World Health Organization (WHO) has identified carbapenem-resistant bacteria as critical pathogens, and the development of novel antibacterials capable of combating infections caused by these bacteria is a priority. Objective : With the aim of finding new alternatives to fight against ARB and especially against carbapenem-resistant bacteria, we have developed a series of living materials formed by incorporating the probiotics Lactobacillus plantarum ( Lp ), Lactobacillus fermentum ( Lf ), and a mixture of both ( L. plantarum + L. fermentum ) into bacterial cellulose (BC). Results : These probiotic-loaded bacterial celluloses inhibited the proliferation of three ARB, including two carbapenem-resistant enterobacteria (CRE), identified as Klebsiella pneumoniae and Enterobacter cloacae , and a carbapenem-resistant Pseudomonas aeruginosa . Interestingly, while the probiotics L. plantarum , L. fermentum , and the mixture of both were found to be inactive against these ARB, they became active once incorporated into BC. Conclusions : The increase in activity is due to the known effect that cells increase their activity once incorporated into a suitable matrix, forming a living material. For the same reasons, the probiotics in the living materials BC- L. plantarum , BC- L. fermentum , and BC- L. plantarum + L. fermentum showed increased stability, allowing them to be stored with bacterial activity for long periods of time (two months). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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