Prevalence, Risk Factors and Antibiotic Resistance of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli in Children Hospitalized with Urinary Tract Infection at King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Autor:	Abdelgalil A; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.; Department of Pediatrics, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia., Saeedi F; Department of Pediatrics, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Metwalli E; Department of Pediatrics, King Abdulaziz University Hospital, Jeddah 21589, Saudi Arabia., Almutairi F; Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Felemban M; Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Albaradei H; Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Aseeri H; Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Mokhtar J; Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Baw W; Al-Noor Specialist Hospital, Makkah 24245, Saudi Arabia., Sayed M; Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.; Department of Pediatrics, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Children (Basel, Switzerland) [Children (Basel)] 2024 Oct 31; Vol. 11 (11). Date of Electronic Publication: 2024 Oct 31.
DOI:	10.3390/children11111332
Abstrakt:	Background/objectives: We aimed to assess the prevalence and risk factors for acquisition of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli ( E. coli ) in children admitted with urinary tract infection (UTI) at a tertiary university hospital in Saudi Arabia, as well as to investigate antibiotic resistance patterns. Methods: This retrospective cross-sectional study involved hospitalized children aged 0-14 years from January 2018 to December 2022 with urine cultures that grew E. coli or ESBL-producing E. coli . Data of the antimicrobial susceptibility for isolated bacteria were collected. Results: This study analyzed 242 urine samples obtained from 119 children with E. coli UTIs. Of these, 20.7% ( n = 50) were ESBL producers. Previous antibiotic use (last 3 months), prophylactic antibiotic use, prior UTI (last 3 months), recurrent UTIs, and underlying co-morbidities ( p = 0.011, <0.001, 0.025, <0.001, and 0.013, respectively) had a significant relationship with increased risk of ESBL E. coli UTIs. Generally, the highest resistance rates in the ESBL-producing isolates were for ampicillin and third-generation cephalosporin. Conversely, all ESBL-positive isolates were sensitive to meropenem, with variable resistance rates to other antibiotics as amikacin, nitrofurantoin, quinolones and trimethoprim/sulfamethoxazole (2%, 8%, 56% and 64%, respectively). Conclusions: There is a high prevalence of ESBL production among children hospitalized with E. coli UTIs. Addressing ESBL UTI risk factors helps to recognize high-risk cases and enhance proper antibiotic use.
Databáze:	MEDLINE
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