| Autor: |
Lai TT; Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1010, Japan.; Department of Surgery, Hanoi Medical University, Hanoi 100000, Vietnam., Ishida M; Department of Pathology, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan., Kosaka H; Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1010, Japan., Matsui K; Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1010, Japan., Matsushima H; Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1010, Japan., Yamamoto H; Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1010, Japan., Kiguchi G; Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1010, Japan., Nguyen KV; Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1010, Japan.; Internal Gastroenterology Department, VNU University of Medicine and Pharmacy, Hanoi 100000, Vietnam., Inoue K; Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1010, Japan., Takada M; Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1010, Japan., Kato H; Department of Mathematics and Statistics in Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan., Hirose Y; Department of Pathology, Osaka Medical and Pharmaceutical University, Osaka 569-8686, Japan., Yoshii K; Department of Mathematics and Statistics in Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan., Kaibori M; Department of Hepatobiliary Surgery, Kansai Medical University, Osaka 573-1010, Japan. |
| Abstrakt: |
Background/Objectives : Adipophilin (ADP) is a protein associated with lipid droplets, and its expression is related to poor prognosis in certain cancers. However, its impact on the survival of patients with colorectal liver metastases (CRLMs) remains unclear. This study investigated the impact of ADP expression on long-term survival following hepatectomy in patients with CRLM. Methods : We retrospectively analyzed 102 consecutive patients who underwent hepatectomy between 2006 and 2022. ADP expression was examined in resected specimens through immunohistochemical staining using tissue microarrays. Long-term outcomes for ADP-positive (n = 51) and ADP-negative (n = 51) groups were compared with Kaplan-Meier survival analysis. Results : We found significantly decreased 5-year recurrence-free survival (RFS) and overall survival (OS) rates for ADP-positive patients relative to ADP-negative patients (29.4% versus 52.1%, respectively; p = 0.001 and 43.7% versus 72.2%, respectively; p = 0.003). Moreover, multivariate Cox hazards analysis demonstrated that patients with ADP-positive CRLM had a worse prognosis after hepatectomy than those with ADP-negative CRLM, as reflected by both RFS (HR 2.46, 95% CI 1.39-4.36, p = 0.002) and OS (HR: 2.89, 95% CI 1.43-5.85, p = 0.003). Conclusions : ADP expression had a significant prognostic impact on the survival of patients with CRLM following liver resection and may aid in optimal treatment planning. |
