Identification of new bioactive molecules in platelet preparation, storage, and transfusion reactions for improved transfusion management.

Autor: Duchez AC; Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France. Anne-Claire.DUCHEZ@efs.sante.fr.; INSERM, Université Jean Monnet, Mines Saint-Étienne, U 1059 SAINBIOSE, F- 42023, Saint-Etienne, France. Anne-Claire.DUCHEZ@efs.sante.fr., Arthaud CA; Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France.; INSERM, Université Jean Monnet, Mines Saint-Étienne, U 1059 SAINBIOSE, F- 42023, Saint-Etienne, France., Eyraud MA; Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France.; INSERM, Université Jean Monnet, Mines Saint-Étienne, U 1059 SAINBIOSE, F- 42023, Saint-Etienne, France., Prier A; Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France.; INSERM, Université Jean Monnet, Mines Saint-Étienne, U 1059 SAINBIOSE, F- 42023, Saint-Etienne, France., Heestermans M; Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France.; INSERM, Université Jean Monnet, Mines Saint-Étienne, U 1059 SAINBIOSE, F- 42023, Saint-Etienne, France., Hamzeh-Cognasse H; INSERM, Université Jean Monnet, Mines Saint-Étienne, U 1059 SAINBIOSE, F- 42023, Saint-Etienne, France., Cognasse F; Etablissement Français du Sang Auvergne-Rhône-Alpes, Saint-Étienne, France.; INSERM, Université Jean Monnet, Mines Saint-Étienne, U 1059 SAINBIOSE, F- 42023, Saint-Etienne, France.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 26; Vol. 14 (1), pp. 29381. Date of Electronic Publication: 2024 Nov 26.
DOI: 10.1038/s41598-024-80632-7
Abstrakt: Platelet concentrates (PCs) intended for transfusion contain bioactive molecules that can be considered Biological Response Modifiers (BRMs), mainly originating from plasma regardless of the preparation process. During storage, NGAL and GDF-15 levels increase in single donor apheresis platelet concentrates (SDA-PC), whereas in buffy coat platelet concentrates (BC-PC), the levels of MIP1α, MCP-3, and HSAA increase, and GDF-15 levels decrease. These molecules, primarily released by leukocytes, may contribute to adverse reactions (ARs) following a PC transfusion. Notably, in SDA-PC or BC-PC transfusions that result in ARs, the levels of NGAL, HSAA, and GDF-15 are significantly elevated, while the levels of MDC and CX3CL1 are significantly reduced compared to transfusions without ARs. These biomarkers could potentially serve as predictors for PCs-induced ARs.
Competing Interests: Declarations. Conflicts of interest: The authors have no conflict of interests to declare.
(© 2024. The Author(s).)
Databáze: MEDLINE
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