Design and Synthesis of Unsymmetric Benzils, Quinoxalines, and Evaluations of their Anticancer Activities against Human Non-Small Lung Cancer Cells.

Autor: Hsu PC; Division of Thoracic Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, 333423, Taiwan.; Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, 333323, Taiwan., Hsu YH; Department of Chemistry, Tamkang University, 251301, Tamsui Dist., New Taipei City, Taiwan., Chang CH; Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, 333324, Taoyuan, Taiwan.; Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, 231405, Taiwan., Shih TL; Department of Chemistry, Tamkang University, 251301, Tamsui Dist., New Taipei City, Taiwan.
Jazyk: angličtina
Zdroj: ChemMedChem [ChemMedChem] 2024 Nov 26, pp. e202400847. Date of Electronic Publication: 2024 Nov 26.
DOI: 10.1002/cmdc.202400847
Abstrakt: Quinoxaline and its derivatives exhibit a broad spectrum of biological activity, making them valuable for various therapeutic applications. However, most quinoxalines are synthetically produced due to their scarcity in nature. In this article, a series of unsymmetric benzils were synthesized and subsequently condensed with 1,2-diaminobenzene to produce unsymmetric quinoxalines. The novel synthetic benzils and quinoxalines were evaluated for their anticancer activities against human non-small-cell lung cancer (NSCLC) cells harboring different gene mutations, to explore their potential as anticancer agents. Among these synthesized molecules, compound 5 g demonstrated inhibitory effects comparable to those of cisplatin.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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