Transcranial MRI-guided Histotripsy Targeting Using MR-thermometry and MR-ARFI.

Autor:	Gupta D; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Kaovasia TP; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Komaiha M; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Nielsen JF; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Allen SP; Department of Electrical and Computer Engineering, Brigham Young University, Provo, UT, USA., Hall TL; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Noll DC; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Xu Z; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: zhenx@umich.edu.
Jazyk:	angličtina
Zdroj:	Ultrasound in medicine & biology [Ultrasound Med Biol] 2025 Feb; Vol. 51 (2), pp. 330-335. Date of Electronic Publication: 2024 Nov 25.
DOI:	10.1016/j.ultrasmedbio.2024.10.010
Abstrakt:	Objective: Transcranial magnetic resonance imaging (MRI)-guided histotripsy has been demonstrated to treat various locations in in vivo swine brain through a human skull. To ensure that the histotripsy treatment is delivered to the intended target location, accurate pre-treatment targeting is necessary. In this work, we investigate the feasibility of MR-thermometry and MR-acoustic radiation force imaging (MR-ARFI) to perform pre-treatment targeting of histotripsy in ex vivo bovine brain through a human skull. Methods: A 700 kHz, 128-element MR-compatible histotripsy array was used to generate histotripsy and tone-burst sonications. The array's electronic drivers were modified to also generate low-amplitude tone-burst sonications to perform MR-thermometry and MR-ARFI-based targeting. Twelve ex vivo bovine brains were treated with histotripsy at 35 MPa, 75 MPa and through a skull at 36 MPa. Before treating the tissue, both MR-ARFI and MR-thermometry were used to estimate the lesion location. Finally, the location of the histotripsy lesion was compared with the focus estimated by MR-thermometry and MR-ARFI. Results: MR-thermometry and MR-ARFI were able to successfully perform pre-treatment targeting of histotripsy using the modified histotripsy array driver. Histotripsy focus was estimated with mean absolute errors along the transverse/longitudinal axis of 2.06/2.95 mm and 2.13/2.51 mm for MR-ARFI and MR-thermometry, respectively. The presence of the human skull reduced the pressure at the focal region, but it did not compromise the targeting accuracy of either of the two methods with a mean absolute error of 1.10/2.91 mm and 1.29/2.91 mm for MR-ARFI and MR-thermometry, respectively. Conclusion: This study demonstrated that transcranial histotripsy pre-treatment targeting is feasible with MR-thermometry and MR-ARFI. Competing Interests: Conflict of interest Z.X., T.H., and the University of Michigan have financial and/or other relationships with HistoSonics Inc. (Copyright © 2024. Published by Elsevier Inc.)
Databáze:	MEDLINE
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