A snapshot of biomanufacturing and the need for enabling research infrastructure.

Autor: Asin-Garcia E; Bioprocess Engineering Group, Wageningen University & Research, Wageningen, 6700, AA, The Netherlands; Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Wageningen, 6708, WE, The Netherlands., Fawcett JD; Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Wageningen, 6708, WE, The Netherlands; Department of Life Sciences, Imperial College London, South Kensington, London, UK., Batianis C; Bioprocess Engineering Group, Wageningen University & Research, Wageningen, 6700, AA, The Netherlands; Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Wageningen, 6708, WE, The Netherlands., Martins Dos Santos VAP; Bioprocess Engineering Group, Wageningen University & Research, Wageningen, 6700, AA, The Netherlands; Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Wageningen, 6708, WE, The Netherlands; LifeGlimmer GmbH, Berlin, Germany. Electronic address: vitor.martinsdossantos@wur.nl.
Jazyk: angličtina
Zdroj: Trends in biotechnology [Trends Biotechnol] 2024 Nov 25. Date of Electronic Publication: 2024 Nov 25.
DOI: 10.1016/j.tibtech.2024.10.014
Abstrakt: Biomanufacturing is crucial for the bioeconomy, with growing investment and attention from industries and governments. Over recent decades numerous biotech companies have been founded, and policies have increasingly prioritised sustainable production methods. However, translation of biotechnological innovations into industrial applications remains challenging, requiring interdisciplinary research infrastructures (RIs) to address gaps in bioprocess development, scalability, and competitiveness. This opinion examines the current landscape of biomanufacturing and highlights the pivotal role of RIs in supporting these transitions. It also proposes enhanced research interoperability, standardisation, and democratisation through meta-workflows that streamline operations within and between RIs. By improving data sharing, process harmonisation, and scalability, these ecosystems can help to overcome technical and economic barriers in a concerted effort towards sustainable, bio-based global manufacturing.
Competing Interests: Declaration of interests V.A.P.M.d.S. has interests in LifeGlimmer GmbH. The other authors have no interests to declare.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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