Efficacy and safety of different antiarrhythmic protocols used for rate control in dogs with secondary atrial fibrillation.

Autor: Romito G; Department of Veterinary Medical Sciences, Alma Mater Studiorum - University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia, Italy. Electronic address: giovanni.romito2@unibo.it., Bertarello M; Department of Veterinary Medical Sciences, Alma Mater Studiorum - University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia, Italy., Mazzoldi C; Department of Veterinary Medical Sciences, Alma Mater Studiorum - University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia, Italy., Fasoli S; Department of Veterinary Medical Sciences, Alma Mater Studiorum - University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia, Italy., Dondi F; Department of Veterinary Medical Sciences, Alma Mater Studiorum - University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia, Italy., Castagna P; Freelance Veterinary Cardiologist, Bologna, Italy., Pelle NG; Freelance Veterinary Cardiologist, Bologna, Italy., Paradies P; Department of Precision and Regenerative Medicine and Ionian Area, Section of Veterinary Clinics, University of Bari, S.p. Valenzano-Casamassima Km 3, 70010 Valenzano, Italy., Valente C; Department of Animal Medicine, Production and Health, University of Padova, Viale dell'Università 16, 35020, Legnaro, Italy., Poser H; Department of Animal Medicine, Production and Health, University of Padova, Viale dell'Università 16, 35020, Legnaro, Italy., Guglielmini C; Department of Animal Medicine, Production and Health, University of Padova, Viale dell'Università 16, 35020, Legnaro, Italy.
Jazyk: angličtina
Zdroj: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology [J Vet Cardiol] 2024 Nov 06; Vol. 57, pp. 8-19. Date of Electronic Publication: 2024 Nov 06.
DOI: 10.1016/j.jvc.2024.10.006
Abstrakt: Introduction/objectives: Studies comparing the effects of antiarrhythmic protocols used for rate control in dogs with secondary atrial fibrillation (AF) are currently limited; therefore, this study aimed to report detailed data on the efficacy and therapy-related side-effects (TRSEs) of different antiarrhythmic protocols in dogs with secondary AF.
Animals, Materials, and Methods: Dogs with secondary AF treated with combination therapy with diltiazem and digoxin (CT Dilt+Digox ), diltiazem monotherapy (MT Dilt ), digoxin monotherapy (MT Digox ), or amiodarone monotherapy (MT Amiod ) were retrospectively evaluated. Signalment, clinical, diagnostic, therapeutic, and outcome data were retrieved. Electrocardiographically, antiarrhythmic efficacy was defined by a reduction in the mean heart rate on Holter monitoring ≤125 beats/minutes. Statistical analysis was performed to compare selected data, including the rate of efficacy and TRSEs as well as the median survival time, between dogs treated with different antiarrhythmic protocols.
Results: Fifty-four dogs were included, with 28 receiving the CT Dilt+Digox and 26 receiving monotherapies (MT Digox  = 16; MT Dilt  = 5; MT Amiod  = 5). The efficacy rate documented in dogs treated with CT Dilt+Digox was significantly higher than that observed in dogs from the composite monotherapy group (i.e., MT Dilt +MT Digox +MT Amiod ) (P=0.048). The rate of TRSEs documented in dogs treated with CT Dilt+Digox was similar to that observed in dogs from the composed monotherapy group (P=0.129). The median survival time documented in dogs treated with CT Dilt+Digox was significantly longer than that observed in dogs of the MT Digox group (P=0.01).
Discussion: In dogs with secondary AF we included, CT Dilt+Digox was well tolerated and provided clinically relevant benefits compared to the use of a single antiarrhythmic drug.
Limitations: Retrospective design; heterogeneous sample size of categories analyzed; clinicopathological data available for many, but not all, dogs.
Conclusions: Our findings support the indication to generally consider CT Dilt+Digox  as a first-line antiarrhythmic treatment in dogs with secondary AF.
Competing Interests: Conflict of Interest Statement The authors do not have any conflicts of interest to disclose.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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