Human biomonitoring health-based guidance values: A case study of the HB2GV Dashboard and DEHP.

Autor: Macey K; Existing Substances Risk Assessment Bureau, Health Canada, Ottawa, ON, Canada. Electronic address: kristin.macey@hc-sc.gc.ca., Lange R; German Environment Agency (UBA), Berlin, Germany. Electronic address: rosa.lange@uba.de., Apel P; German Environment Agency (UBA), Berlin, Germany. Electronic address: petra.apel@uba.de., Poddalgoda D; Existing Substances Risk Assessment Bureau, Health Canada, Ottawa, ON, Canada. Electronic address: devika.poddalgoda@hc-sc.gc.ca., Calafat AM; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: aic7@cdc.gov., Kolossa-Gehring M; German Environment Agency (UBA), Berlin, Germany. Electronic address: marike.kolossa@uba.de., LaKind JS; LaKind Associates, LLC, Catonsville, MD, USA; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: lakindassoc@gmail.com., Melnyk LJ; U.S. Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessment, Cincinnati, OH, USA. Electronic address: melnyk.lisa@epa.gov., Nakayama SF; Japan Environment and Children's Study Programme Office, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan. Electronic address: fabre@nies.go.jp., St-Amand A; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada. Electronic address: annie.st-amand@hc-sc.gc.ca., Pollock T; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada. Electronic address: tyler.pollock@hc-sc.gc.ca.
Jazyk: angličtina
Zdroj: International journal of hygiene and environmental health [Int J Hyg Environ Health] 2025 Jan; Vol. 263, pp. 114490. Date of Electronic Publication: 2024 Nov 25.
DOI: 10.1016/j.ijheh.2024.114490
Abstrakt: In 2022, the International Society of Exposure Science (ISES) International Human Biomonitoring (i-HBM) Working Group launched a free, online repository of biomonitoring guidance values referred to as the Human Biomonitoring Health-Based Guidance Value (HB2GV) Dashboard. The goal of the Dashboard is to assist global human biomonitoring data users (e.g., risk assessors, risk managers) and human biomonitoring programs with a readily available compilation of guidance values for the general population. The Dashboard contains approximately 600 HB2GVs for over 150 chemicals or their metabolites. Although there are many different types of HB2GVs, most are Biomonitoring Equivalents (BEs), Human Biomonitoring (HBM-I and HBM-II) values, or Human Biomonitoring Guidance Values (HBM-GVs). For users new to human biomonitoring, understanding how the different types of HB2GVs are derived and how to interpret those values in the context of human biomonitoring data can be difficult. Therefore, there is a need to inform users of the differences among available guidance values and to help users identify the HB2GV that could be most suitable for their purposes. Here, we summarize the derivation of HB2GVs for a case study chemical, di-(2-ethylhexyl) phthalate (DEHP). We selected DEHP as there are 36 unique HB2GVs available from three of the most common types of guidance values (i.e., BE, HBM-I value, HBM-GV). We also compare the available HB2GVs with a focus on the differences among their derivation methods, relative quality and confidence, and interpretation. This case study provides guidance on the use of existing HB2GVs for health-based interpretation of human biomonitoring data that may be applied to other chemicals. As with any other type of guidance or regulatory value (e.g., RfDs, MRLs), thoughtful selection and use are strongly encouraged. Appropriately interpreting HBM data with the aid of guidance values can result in improved decision making which, ultimately, could lead to better protection of public health.
Competing Interests: Conflicts of Interest The findings and conclusion in this paper are those of the authors and do not necessarily reflect the views of their respective employers. Use of trade names is for identification only and does not imply endorsement by the EPA, CDC, or the US Department of Health and Human Services. The research presented was not performed or funded by EPA and was not subject to EPA's quality system requirements. The views expressed in this article are those of the authors and do not necessarily represent the views or the policies of the U.S. Environmental Protection Agency.
(Crown Copyright © 2024. Published by Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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