Pediatric Solitary Epithelioid Histiocytoma of the Face.
| Autor: | Yuksel SS; Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin., North PE; Department of Pathology, Medical College of Wisconsin, Wauwatosa, WI., Y K Lin K; Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of craniofacial surgery [J Craniofac Surg] 2024 Nov 26. Date of Electronic Publication: 2024 Nov 26. |
| DOI: | 10.1097/SCS.0000000000010926 |
| Abstrakt: | Background: Solitary epithelioid histiocytoma, also known as reticulohistiocytoma, is a rare benign histiocytic proliferation with an unreported incidence that commonly presents as a superficial nodule involving the trunk and extremities of adults. Pathology shows dermal histiocytic infiltration composed of large, eosinophilic histiocytes with "glassy" cytoplasm and oncocytic macrophages. When presenting as part of a systemic disorder, it is called multicentric reticulohistiocytosis, a rare and more aggressive condition characterized by multiple skin and mucosal lesions and arthritis. Clinical Case: A 5-year-old African American male patient presented to the pediatric plastic surgery clinic with a lesion of his lower lip 3 months after its initial appearance. Ultrasound identified a hypoechoic heterogenous nodule with increased vascularity. The lesion was excised in the operating room. Pathology revealed a highly cellular nodular proliferation of large epithelioid histiocytes with abundant glassy, lightly eosinophilic cytoplasm and mildly pleomorphic, generally eccentric, round-to-elongated nuclei. The large epithelioid cells were strongly and consistently positive for CD163 and CD68. The diagnosis was determined to be a benign histiocytic proliferation most consistent with solitary epithelioid histiocytoma. At 2-week and 2-month follow-up, the area was healing well and there was no evidence of recurrence. Conclusion: This is an unusual presentation of a rare but benign histiocytic proliferation on the face of a young child. When pediatric patients are referred to a plastic surgery clinic for excisional biopsy of facial lesions, it is important to be aware of the broad range of differential diagnoses, including histiocytic proliferations, to treat the patient appropriately. Competing Interests: The authors report no conflicts of interest. (Copyright © 2024 by Mutaz B. Habal, MD.) |
| Databáze: | MEDLINE |
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