| Autor: |
Roman-Ramos H; Laboratório de Biotecnologia, Programa de Pós-Graduação em Medicina, Universidade Nove de Julho (UNINOVE), São Paulo 01504-001, SP, Brazil., Ho PL; Centro Bioindustrial, Instituto Butantan, São Paulo 05503-900, SP, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
Toxins [Toxins (Basel)] 2024 Oct 25; Vol. 16 (11). Date of Electronic Publication: 2024 Oct 25. |
| DOI: |
10.3390/toxins16110458 |
| Abstrakt: |
This comprehensive review explores the cutting-edge advancements in snake venom research, focusing on the integration of proteomics, genomics, transcriptomics, and bioinformatics. Highlighting the transformative impact of these technologies, the review delves into the genetic and ecological factors driving venom evolution, the complex molecular composition of venoms, and the regulatory mechanisms underlying toxin production. The application of synthetic biology and multi-omics approaches, collectively known as venomics, has revolutionized the field, providing deeper insights into venom function and its therapeutic potential. Despite significant progress, challenges such as the functional characterization of toxins and the development of cost-effective antivenoms remain. This review also discusses the future directions of venom research, emphasizing the need for interdisciplinary collaborations and new technologies (mRNAs, cryo-electron microscopy for structural determinations of toxin complexes, synthetic biology, and other technologies) to fully harness the biomedical potential of venoms and toxins from snakes and other animals. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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