| Autor: |
Alqudah SM; Faculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan., Hailat M; Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan., Zakaraya Z; Faculty of Pharmacy, Pharmacological and Diagnostic Research Centre (PDRC), Al-Ahliyya Amman University, Amman 19328, Jordan., Abu Dayah AA; Faculty of Pharmacy, Pharmacological and Diagnostic Research Centre (PDRC), Al-Ahliyya Amman University, Amman 19328, Jordan., Abu Assab M; Faculty of Pharmacy, Zarqa University, Zarqa 13110, Jordan., Alarman SM; Faculty of Pharmacy, Mutah University, Al Karak 61710, Jordan., Awad RM; Faculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan., Hamad MF; Faculty of Medicine, Al-Balqa Applied University, Al-Salt 19117, Jordan., Vicaș LG; Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania., Abu Dayyih W; Faculty of Pharmacy, Mutah University, Al Karak 61710, Jordan. |
| Abstrakt: |
Diabetes mellitus (DM) is a major global health concern characterized by high blood glucose levels. This study investigates the effects of Opuntia ficus-indica (cactus) juice and empagliflozin, both alone and in combination, on glycated hemoglobin (HbA1c) levels in healthy and streptozotocin-induced diabetic rats. Eighty Wistar albino male rats were divided into eight groups, with four groups being diabetic. Treatment options included cactus juice, empagliflozin, or both. HbA1c levels were measured at baseline and 100 days later using ELISA. In diabetic and non-diabetic rats treated with cactus juice or empagliflozin, HbA1c levels were significantly reduced, but diabetic rats had significantly lower HbA1c values than non-diabetic rats. The combined treatment provided no additional benefits over individual therapies. These findings indicate that cactus juice and empagliflozin effectively lower HbA1c levels, making their use a promising complementary approach to diabetes management. However, the combined treatment of Opuntia ficus-indica juice and empagliflozin did not yield additional reductions in HbA1c levels compared to individual treatments, with no significant synergistic effects observed throughout the study period. More research is needed to better understand the clinical applications and mechanisms in humans. |
