| Autor: |
Rajamanikandan R; Department of Physics, Gachon University, Seongnam-si 13120, Republic of Korea.; Gachon Bionano Research Institute, Gachon University, Seongnam-si 13120, Republic of Korea., Sasikumar K; Department of Physics, Gachon University, Seongnam-si 13120, Republic of Korea.; Gachon Bionano Research Institute, Gachon University, Seongnam-si 13120, Republic of Korea., Ju H; Department of Physics, Gachon University, Seongnam-si 13120, Republic of Korea.; Gachon Bionano Research Institute, Gachon University, Seongnam-si 13120, Republic of Korea. |
| Abstrakt: |
We reported the gold/silver core-shell nanoparticles (Au core @Ag shell NPs) functionalized with β-cyclodextrin (β-CD) as versatile nano-agents demonstrated for human urine-based biosensing of cysteamine and catalytic conversion from nitrobenzene (NB) to aniline. First, the hybrid bimetallic nanoparticles, i.e., β-CD-Au core @Ag shell NPs, constituted a colorimetric sensing platform based on localized surface plasmons, enabling cysteamine (Cyst) to be detected in a remarkably rapid manner, i.e., within 2 min, which was greatly shortened in comparison with that of our previous report. This was due largely to use of β-CD being effectively replaceable by Cyst. The detection of Cyst was demonstrated using human urine specimens in the linear range of 25-750 nM with a limit of detection of 1.83 nM. Excellent specificity in detecting Cyst was also demonstrated against potential interfering molecules. Meanwhile, the β-CD-Au core @Ag shell NPs were demonstrated as nanocatalysts for converting NB to aniline with efficiency enhanced by more than three-fold over the pure gold nanoparticles previously reported, due to the dual functions of the structural core-shell. The demonstrated versatile features of the hybrid nanoparticles can find applications in human urine-based biosensors for Cyst detection, and in the screening of Cyst-containing drugs, while detoxicating NB for ecological protection in aqueous media. |
