Effect of Donor-Recipient Sex Mismatch on the Outcome of Simultaneous Pancreas-Kidney Transplant.
| Autor: | Wei J; From the Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University; and the Department of Kidney Transplantation, Tianjin First Central Hospital, Tianjin, China., Zhao J, Cao Y, Niu Y |
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| Jazyk: | angličtina |
| Zdroj: | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation [Exp Clin Transplant] 2024 Oct; Vol. 22 (10), pp. 775-785. |
| DOI: | 10.6002/ect.2024.0209 |
| Abstrakt: | Objectives: There have been conflicting reports detailing the effect of sex match between transplant donor and recipient on the outcome of solid-organ transplants. We investigated the effect of donor-recipient sex match on allograft function and survival outcomes after simultaneous pancreas-kidney transplant at a single transplant center in China. Materials and Methods: We retrospectively reviewed data for 120 simultaneous pancreas-kidney transplant recipients treated at our center during the period from January 2015 to January 2020. Patients were divided into a sex-matched group (n = 88) and a sex-mismatched group (n = 32). Kidney and pancreatic allograft function and survival outcomes were compared between the 2 groups. Propensity score matching was used to enhance the comparability of the study participants. After propensity score matching, 24 patients were included in the sex-matched group, and 24 patients were in the sex-mismatched group. Results: The median follow-up duration was 23 months. Before propensity score matching, pancreatic allograft death-censored survival rates at 1 year and 3 years were 94.30% and 92.90% in the sex-matched group and 100% and 100% in the sex-mismatched group, respectively. However, after propensity score matching, there was a further reduction in pancreatic allograft death-censored survival in the sex-matched group. At follow-up, the pancreas allograft death-censored survival rate was significantly less in the sex-matched group versus the sex-mismatched group (after propensity score matching; P = .042). For other parameters, such as estimated glomerular filtration rate, fasting blood glucose, glycated hemoglobin, allograft rejection, patient survival, and kidney allograft death-censored survival, there were no significant differences between the sex-matched and sex-mismatched groups. Conclusions: Donor-recipient sex match significantly reduced pancreatic allograft survival, indicating that more attention should be focused on sex-matched recipients for development of donor allocation and postoperative monitoring strategies. |
| Databáze: | MEDLINE |
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