Anti-interleukin-5/anti-interleukin-5 receptor α treatment improves self-reported work productivity in patients with severe eosinophilic asthma: a prospective cohort trial.

Autor:	Brinkmann L; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; These authors contributed equally., Fuge J; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), member of the German Center for Lung Research (DZL), Hannover, Germany.; These authors contributed equally., Welte T; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), member of the German Center for Lung Research (DZL), Hannover, Germany., Suhling H; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), member of the German Center for Lung Research (DZL), Hannover, Germany.; These authors contributed equally., Drick N; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), member of the German Center for Lung Research (DZL), Hannover, Germany.; These authors contributed equally.
Jazyk:	angličtina
Zdroj:	ERJ open research [ERJ Open Res] 2024 Nov 25; Vol. 10 (6). Date of Electronic Publication: 2024 Nov 25 (Print Publication: 2024).
DOI:	10.1183/23120541.00374-2024
Abstrakt:	Background: Severe asthma affects the working life of millions of people worldwide. Interleukin (IL)-5/anti-interleukin-5 receptor α (IL-5Rα) antibodies are highly effective in reducing symptoms in patients with severe eosinophilic asthma. We analysed effects of anti-IL-5/anti-IL-5Rα treatment on self-reported productivity and absenteeism at work in patients with severe eosinophilic asthma. Methods: In this prospective single-centre study, patients with severe eosinophilic asthma received a questionnaire assessing their actual occupational status and the influence asthma has on their work life, productivity and missed days at work prior to initiation of antibody treatment and after 6 and 12 months of therapy. Among others, the Work Productivity and Activity Impairment Questionnaire: Specific Health Problem (WPAI:SHP) was used. Results: Out of 54 patients with a median age of 60 years, 27 (50%) were employed. In addition to an increase in asthma control and lung function, self-reported productivity increased significantly with a decrease on the WPAI:SHP from 30% (interquartile range (IQR) 20-50%) to 10% (IQR 0-27.5%) under treatment (p=0.001). Furthermore, self-reported missed days at work were reduced from 2 days·month -1 (IQR 1.75-6 days·month -1 ) to 0 days·month -1 (IQR 0-2 days·month -1 ; p=0.067). At baseline 22 employed patients (81%) stated they were affected at work by their asthma. After 12 months of treatment, this number decreased to eight patients (30%; p=0.038). Conclusions: This prospective analysis could prove the substantial impact severe asthma has on patients' working life. Anti-IL-5/anti-IL-5Rα treatment in patients with severe eosinophilic asthma leads to a significant increase in self-reported productivity at work, and after 12 months of treatment patients state substantially fewer negative effects on their working situation. Competing Interests: Conflict of interest: L. Brinkmann has no relevant conflicts of interest. J. Fuge reports speaker fees from AstraZeneca. T. Welte reported personal fees from AstraZeneca, GSK and Sanofi Aventis, and his institution received research grants from the German Ministry of Research and Education. H. Suhling reports speaker fees from AstraZeneca, GSK and Novartis. N. Drick reports speaker fees for AstraZeneca. (Copyright ©The authors 2024.)
Databáze:	MEDLINE
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