Clinical and biological underpinnings of longitudinal atrophy pattern progression in Alzheimer's disease.

Autor:	Ferraro PM; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Filippi L; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Ponzano M; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy., Signori A; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy., Orso B; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Massa F; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Arnaldi D; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Caneva S; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Argenti L; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Losa M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Lombardo L; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Mattioli P; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Costagli M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Gualco L; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Pulze M; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Plantone D; Centre for Precision and Translational Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy., Brugnolo A; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Girtler N; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Diociasi A; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy., Garbarino S; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Villani F; IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Sormani MP; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy., Uccelli A; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Roccatagliata L; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy., Pardini M; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024 Nov 25, pp. 13872877241299843. Date of Electronic Publication: 2024 Nov 25.
DOI:	10.1177/13872877241299843
Abstrakt:	Background: Magnetic resonance imaging (MRI) has recently enabled to identify four distinct Alzheimer's disease (AD) subtypes: hippocampal sparing (HpSp), typical AD (tAD), limbic predominant (Lp), and minimal atrophy (MinAtr). To date, however, the natural history of these subtypes, especially regarding the presence of subjects switching to other MRI patterns and their clinical and biological differences, remains poorly understood. Objective: To investigate the clinical and biological underpinnings of longitudinal atrophy pattern progression in AD. Methods: 251 AD patients (16 with significant memory concern, 66 with early mild cognitive impairment (MCI), 125 with late MCI, and 44 with AD dementia) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were assigned to their baseline MRI atrophy subtype using Freesurfer-derived cortical:hippocampal volumes ratio. Switching to other MRI patterns was investigated on longitudinal scans, and patients were accordingly classified as " switching " and " stable ". Logistic regression models were applied to identify predictors of switching to other MRI patterns. Results: 40% of Lp, 26% of HpSp, and 35% of MinAtr cases switched to other MRI patterns, with tAD representing the destination subtype of all switching HpSp and Lp, and the majority of MinAtr. At baseline significant clinical, cognitive and biomarkers differences were observed across the four subtypes. Only clinical and cognitive variables, however, were significantly associated with switch to other MRI patterns. Conclusions: Our results suggest convergent directions of disease progression across atypical and typical AD forms, at least in a subset of AD subjects, and highlight the importance of deep-phenotyping approaches to understand AD heterogeneity. Competing Interests: Declaration of conflicting interestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Federico Massa is an Editorial Board Member of this journal but was not involved in the peer-review process of this article nor had access to any information regarding its peer-review. The remaining authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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