Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study.

Autor: Magnus MC; Centre for Fertility and Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, Oslo, 0213, Norway. Maria.Christine.Magnus@fhi.no., Lee Y; Centre for Fertility and Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, Oslo, 0213, Norway., Carlsen EØ; Centre for Fertility and Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, Oslo, 0213, Norway., Arge LA; Centre for Fertility and Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, Oslo, 0213, Norway., Jugessur A; Centre for Fertility and Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, Oslo, 0213, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway., Kvalvik LG; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway., Morken NH; Centre for Fertility and Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, Oslo, 0213, Norway.; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway., Ramlau-Hansen CH; Department of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark., Myrskyla M; Max Planck Institute for Demographic Research, Rostock, Germany.; Helsinki Institute for Demography and Population Health, University of Helsinki, Helsinki, Finland.; Max Planck, University of Helsinki Center for Social Inequalities in Population Health, Rostock, Germany., Magnus P; Centre for Fertility and Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, Oslo, 0213, Norway., Håberg SE; Centre for Fertility and Health, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, Oslo, 0213, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Jazyk: angličtina
Zdroj: BMC medicine [BMC Med] 2024 Nov 25; Vol. 22 (1), pp. 554. Date of Electronic Publication: 2024 Nov 25.
DOI: 10.1186/s12916-024-03780-7
Abstrakt: Background: Few studies have examined associations between maternal epigenetic age acceleration and adverse birth outcomes, and none have investigated paternal epigenetic age acceleration. Our objective was to assess the associations of parental (both maternal and paternal) epigenetic age acceleration in relation to birth outcomes.
Methods: Parental epigenetic age was estimated using seven established epigenetic clocks in 2198 mothers and 2193 fathers from the Norwegian Mother, Father, and Child Cohort Study (MoBa). Individual epigenetic age acceleration was then calculated as residuals from linear regressions of estimates from the epigenetic clocks on chronological age. Further, linear regression was used to analyze differences in continuous outcomes (gestational length and standardized birthweight), while logistic regression was used for binary outcomes (preterm birth, post-term birth, small-for-gestational age [SGA], large-for-gestational age [LGA], and pre-eclampsia), adjusting for chronological age, parity, educational level, smoking, and BMI.
Results: Increasing maternal, but not paternal, epigenetic age acceleration was associated with decreased gestational length for five out of six clocks, with adjusted estimates ranging from a mean 0.51-day decrease (95% CI - 1.00, - 0.02; p-value 0.043) for the Horvath clock to a 0.80-day decrease (95% CI - 1.29, - 0.31; p-value 0.002) for the Levine clock. An association with increasing maternal epigenetic age acceleration according to the DunedinPACE clock was also seen with greater standardized birthweight [mean difference 0.08 (95% CI 0.04, 0.12; p-value < 0.001]. These results were also reflected in an increased risk of spontaneous preterm birth and LGA. No associations were observed with post-term birth, SGA, or pre-eclampsia.
Conclusions: Maternal, but not paternal, epigenetic age acceleration is associated with shorter pregnancies and an increased risk of spontaneous preterm birth. This may suggest that women's biological age acceleration, including factors such as metabolic and physiologic state, is an additional risk factor for preterm delivery, beyond chronological age.
Competing Interests: Declarations. Ethics approval and consent to participate: Establishment and initial data collection in MoBa was based on a license from the Norwegian Data Protection Agency and approval from The Regional Committees for Medical and Health Research Ethics. The MoBa cohort is currently regulated by the Norwegian Health Registry Act. The current study was approved by the Regional Committees for Medical and Health Research Ethics of South/East Norway (reference number: 2017/1362). All participants provided a written informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: