Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM-REM sleep cycle.

Autor: Osorio-Forero A; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.; Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands., Foustoukos G; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland., Cardis R; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland., Cherrad N; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland., Devenoges C; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland., Fernandez LMJ; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland., Lüthi A; Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland. anita.luthi@unil.ch.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2024 Nov 25. Date of Electronic Publication: 2024 Nov 25.
DOI: 10.1038/s41593-024-01822-0
Abstrakt: The noradrenergic locus coeruleus (LC) regulates arousal levels during wakefulness, but its role in sleep remains unclear. Here, we show in mice that fluctuating LC neuronal activity partitions non-rapid-eye-movement sleep (NREMS) into two brain-autonomic states that govern the NREMS-REMS cycle over ~50-s periods; high LC activity induces a subcortical-autonomic arousal state that facilitates cortical microarousals, whereas low LC activity is required for NREMS-to-REMS transitions. This functional alternation regulates the duration of the NREMS-REMS cycle by setting permissive windows for REMS entries during undisturbed sleep while limiting these entries to maximally one per ~50-s period during REMS restriction. A stimulus-enriched, stress-promoting wakefulness was associated with longer and shorter levels of high and low LC activity, respectively, during subsequent NREMS, resulting in more microarousal-induced NREMS fragmentation and delayed REMS onset. We conclude that LC activity fluctuations are gatekeepers of the NREMS-REMS cycle and that this role is influenced by adverse wake experiences.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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