Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications.
Autor: | Zheng Y; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Guangzhou Institute of Respiratory Health Guangzhou, Guangzhou, China.; State Key Laboratory of Respiratory Diseases, Guangzhou, China., Sun J; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Guangzhou Institute of Respiratory Health Guangzhou, Guangzhou, China.; State Key Laboratory of Respiratory Diseases, Guangzhou, China.; Guangzhou National Laboratory, Guangzhou, China., Luo Z; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.; Guangzhou Institute of Respiratory Health Guangzhou, Guangzhou, China.; State Key Laboratory of Respiratory Diseases, Guangzhou, China.; Guangzhou National Laboratory, Guangzhou, China., Li Y; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. dryiminli@vip.163.com.; Guangzhou Institute of Respiratory Health Guangzhou, Guangzhou, China. dryiminli@vip.163.com.; State Key Laboratory of Respiratory Diseases, Guangzhou, China. dryiminli@vip.163.com.; Guangzhou National Laboratory, Guangzhou, China. dryiminli@vip.163.com., Huang Y; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. yongbo2046@163.com.; Guangzhou Institute of Respiratory Health Guangzhou, Guangzhou, China. yongbo2046@163.com.; State Key Laboratory of Respiratory Diseases, Guangzhou, China. yongbo2046@163.com. |
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Jazyk: | angličtina |
Zdroj: | Cell death & disease [Cell Death Dis] 2024 Nov 26; Vol. 15 (11), pp. 859. Date of Electronic Publication: 2024 Nov 26. |
DOI: | 10.1038/s41419-024-07244-x |
Abstrakt: | Regulated cell death (RCD) refers to the form of cell death that can be regulated by various biomacromolecules. Each cell death modalities have their distinct morphological changes and molecular mechanisms. However, intense evidences suggest that lipid peroxidation can be the common feature that initiates and propagates the cell death. Excessive lipid peroxidation alters the property of membrane and further damage the proteins and nucleic acids, which is implicated in various human pathologies. Here, we firstly review the classical chain process of lipid peroxidation, and further clarify the current understanding of the myriad roles and molecular mechanisms of lipid peroxidation in various RCD types. We also discuss how lipid peroxidation involves in diseases and how such intimate association between lipid peroxidation-driven cell death and diseases can be leveraged to develop rational therapeutic strategies. Competing Interests: Competing interests: The authors declare no competing interests. Consent for publication: All authors agreed to publication. (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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