Comparative lifespan and healthspan of nonhuman primate species common to biomedical research.

Autor: Huber HF; Texas Biomedical Research Institute, San Antonio, TX, USA. hhuber@txbiomed.org., Ainsworth HC; Wake Forest University School of Medicine, Winston-Salem, NC, USA., Quillen EE; Wake Forest University School of Medicine, Winston-Salem, NC, USA., Salmon A; University of Texas Health Science Center, San Antonio, TX, USA., Ross C; Texas Biomedical Research Institute, San Antonio, TX, USA., Azhar AD; Primate Research Center, IPB University, Bogor, Indonesia., Bales K; California National Primate Research Center, Davis, CA, USA.; University of California, Davis, CA, USA., Basso MA; Washington National Primate Research Center, Seattle, WA, USA., Coleman K; Oregon National Primate Research Center, Hillsboro, OR, USA.; Oregon Health & Science University, Portland, OR, USA., Colman R; Wisconsin National Primate Research Center, Madison, WI, USA., Darusman HS; Primate Research Center, IPB University, Bogor, Indonesia.; School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia., Hopkins W; The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA.; Emory National Primate Research Center, Atlanta, GA, USA., Hotchkiss CE; Washington National Primate Research Center, Seattle, WA, USA., Jorgensen MJ; Wake Forest University School of Medicine, Winston-Salem, NC, USA., Kavanagh K; Wake Forest University School of Medicine, Winston-Salem, NC, USA.; University of Tasmania, Hobart, TAS, Australia., Li C; University of Wyoming, Laramie, WY, USA., Mattison JA; National Institute On Aging, National Institutes of Health, Gaithersburg, MD, USA., Nathanielsz PW; Texas Biomedical Research Institute, San Antonio, TX, USA.; University of Wyoming, Laramie, WY, USA., Saputro S; Primate Research Center, IPB University, Bogor, Indonesia., Scorpio DG; Texas Biomedical Research Institute, San Antonio, TX, USA.; Envol Biomedical, Immokalee, FL, USA., Sosa PM; California National Primate Research Center, Davis, CA, USA., Vallender EJ; Tulane National Primate Research Center, Covington, LA, USA.; New England Primate Research Center, Southborough, MA, USA., Wang Y; Wake Forest University School of Medicine, Winston-Salem, NC, USA., Zeiss CJ; Yale University School of Medicine, New Haven, CT, USA., Shively CA; Wake Forest University School of Medicine, Winston-Salem, NC, USA., Cox LA; Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2024 Nov 25. Date of Electronic Publication: 2024 Nov 25.
DOI: 10.1007/s11357-024-01421-8
Abstrakt: There is a critical need to generate age- and sex-specific survival curves to characterize chronological aging consistently across nonhuman primates (NHP) used in biomedical research. Sex-specific Kaplan-Meier survival curves were computed in 12 translational aging models: baboon, bonnet macaque, chimpanzee, common marmoset, coppery titi monkey, cotton-top tamarin, cynomolgus macaque, Japanese macaque, pigtail macaque, rhesus macaque, squirrel monkey, and vervet/African green. After employing strict inclusion criteria, primary results are based on 12,269 NHPs that survived to adulthood and died of natural/health-related causes. A secondary analysis was completed for 32,616 NHPs that died of any cause. Results show a pattern of reduced male survival among catarrhines (African and Asian primates), especially macaques, but not platyrrhines (Central and South American primates). For many species, median lifespans were lower than previously reported. An important consideration is that these analyses may offer a better reflection of healthspan than lifespan since research NHPs are typically euthanized for humane welfare reasons before their natural end of life. This resource represents the most comprehensive characterization of sex-specific lifespan and age-at-death distributions for 12 biomedically relevant species, to date. These results clarify relationships among NHP ages and provide a valuable resource for the aging research community, improving human-NHP age equivalencies, informing investigators of expected survival rates, providing a metric for comparisons in future studies, and contributing to understanding of factors driving lifespan differences within and among species.
Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to American Aging Association.)
Databáze: MEDLINE
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