Molecular Secrets Revealed: How Diabetes may be Paving the Way for Leukemia.

Autor: Goleij P; USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran. medgenetic.1991@gmail.com.; Department of Genetics, Faculty of Biology, Sana Institute of Higher Education, Sari, Iran. medgenetic.1991@gmail.com., Khazeei Tabari MA; School of Medicine, Mazandaran University of Medical Sciences, Mazandaran, Iran., Ahmed ARD; Faculty of Medicine, University of Medical Science and Technology, Khartoum, Sudan., Mohamed LME; Faculty of Medicine and Health Sciences, Omdurman Islamic University, Khartoum, Sudan., Saleh GAH; Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Abdu Hassan MTM; Faculty of Medicine, University of Medical Science and Technology, Khartoum, Sudan., Moahmmednoor AGM; Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Khan H; Department of Pharmacy, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan. haroonkhan@awkum.edu.pk.; Department of Pharmacy, Korea University, Sejong, 20019, South Korea. haroonkhan@awkum.edu.pk.
Jazyk: angličtina
Zdroj: Current treatment options in oncology [Curr Treat Options Oncol] 2024 Nov 25. Date of Electronic Publication: 2024 Nov 25.
DOI: 10.1007/s11864-024-01281-6
Abstrakt: Opinion Statement: Type 2 Diabetes Mellitus (T2DM) and leukemia are two major global health concerns, both contributing significantly to morbidity and mortality. Epidemiological evidence demonstrates a strong correlation between T2DM and an increased risk of leukemia, particularly driven by insulin resistance, hyperglycemia, and the resultant metabolic dysregulation. Key shared risk factors, including obesity and chronic inflammation, create a conducive environment for leukemogenesis, intensifying cancer cell proliferation and resistance to standard therapies. Insulin resistance, in particular, triggers oncogenic pathways such as PI3K/AKT and MAPK, exacerbating the aggressive phenotype seen in leukemia patients with T2DM. Additionally, clonal hematopoiesis of indeterminate potential (CHIP) is implicated in the higher leukemia risk observed in diabetic populations, especially among the elderly. Molecular mechanisms like the insulin-like growth factor (IGF) system further highlight the intricate link between these diseases, promoting survival and proliferation of leukemia cells. The coexistence of T2DM in leukemia patients is associated with poorer prognostic outcomes, including increased susceptibility to infections, reduced survival, and greater treatment resistance. Antidiabetic agents, notably metformin and pioglitazone, show promise in enhancing chemotherapy efficacy and improving patient outcomes by targeting metabolic pathways. These results highlight the need for comprehensive treatment approaches that target both metabolic abnormalities and cancer-related mechanisms in patients suffering from both T2DM and leukemia.
Competing Interests: Declarations. Ethical Standards: The manuscript does not contain clinical studies or patient data. Financial Interests: The authors declare they have no financial interests. Non-financial Interests: None. Conflict of Interest: The authors declare no competing interests. Human and Animal Rights and Informed Consent: This article does not contain any studies with human or animal subjects performed by any of the authors.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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