| Autor: |
Chang Z; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China. yejiahai@njust.edu.cn., Li S; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China. chenyc@nju.edu.cn., Ye JH; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China. yejiahai@njust.edu.cn., Lin F; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China. yejiahai@njust.edu.cn., Chen Y; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China. chenyc@nju.edu.cn., Guo Z; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China. chenyc@nju.edu.cn., Gong X; School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China. yejiahai@njust.edu.cn. |
| Abstrakt: |
A novel near-infrared fluorescent probe TM2 based on a rhodamine-bearing framework was disclosed with a large Stokes shift (100 nm). TM2 exhibits highly selective recognition for Cu 2+ in EtOH/H 2 O (1 : 1, v/v) solution with a low detection limit (2.3 μM) and a wide detection range (0-50 μM). Detection of Cu 2+ is undisturbed at physiological pH levels of 5-9. This recognition mechanism is attributed to the formation of a 1 : 1 complex between TM2 and Cu 2+ , validated by Job's plot, 1 H NMR titration, and LC-MS experiments. Moreover, the successful fluorescence imaging of Cu 2+ both in vitro and in vivo was also accomplished. |
