Beyond the Norm: Gastroenteritis-Induced Atypical Hemolytic Uremic Syndrome in the Absence of Complement Dysfunction.
| Autor: | Bernardino R; Internal Medicine, Hospital Curry Cabral - Centro Hospitalar Universitário de Lisboa Central, Lisboa, PRT., Leão R; Internal Medicine, NOVA Medical School, Lisboa, PRT.; Internal Medicine, Unidade Local de Saúde de São José, Lisboa, PRT., Ghiletchi A; Internal Medicine, Centro Hospitalar Universitário de Lisboa Central, Lisboa, PRT., Coelho C; Internal Medicine, Centro Hospitalar Universitário de Lisboa Central, Lisboa, PRT., Sampaio B; Internal Medicine, Centro Hospitalar Universitário de Lisboa Central, Lisboa, PRT. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Oct 23; Vol. 16 (10), pp. e72182. Date of Electronic Publication: 2024 Oct 23 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.72182 |
| Abstrakt: | Atypical hemolytic uremic syndrome (aHUS) is a complex disorder characterized by thrombotic microangiopathy, typically driven by complement dysregulation. While most cases of aHUS are linked to genetic abnormalities in the complement system, sporadic instances occur without identifiable genetic or complement involvement. This report discusses the case of a 38-year-old woman who developed aHUS following gastroenteritis, marked by acute kidney injury requiring dialysis, yet displayed normal complement levels. This case highlights the diagnostic and management challenges in aHUS when traditional disease markers are absent and emphasizes the importance of tailored therapeutic approaches. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Bernardino et al.) |
| Databáze: | MEDLINE |
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