Exploring the Interplay Between Senescent Osteocytes and Bone Remodeling in Young Rodents.

Autor:	Song I; Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea., Kim PJ; School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea., Choi YJ; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon 16499, Republic of Korea., Chung YS; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon 16499, Republic of Korea., Lee S; Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 59 Yatap-ro, Bundang-gu, Seongnam-si 13496, Republic of Korea., Baek JH; Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea.; Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea., Woo KM; Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea.; Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Jazyk:	angličtina
Zdroj:	Journal of aging research [J Aging Res] 2024 Nov 16; Vol. 2024, pp. 4213141. Date of Electronic Publication: 2024 Nov 16 (Print Publication: 2024).
DOI:	10.1155/2024/4213141
Abstrakt:	This study identifies senescent osteocytes in the femur and tibia of young rodents and explores their role in bone remodeling. The proximity of osteoclasts to senescent osteocytes was observed, which is a new finding. Cultured osteocytes, sorted using a podoplanin antibody in FACS, exhibited osteocytic characteristics and increased senescence-related genes. Senescent osteocytes secreted cytokines associated with senescence, remodeling, and inflammation. Notably, IGF1 and MMP2 were elevated in podoplanin-positive (pdpn + ) osteocytes. Migration assays demonstrated significant osteoclast precursor migration towards senescent osteocytes, further confirmed by co-culture experiments leading to osteoclast differentiation. These findings suggest that senescent osteocytes have a pivotal role in initiating bone resorption, with recruitment of osteoclast precursors during early bone remodeling stages. In conclusion, our research enhances our understanding of complicated bone remodeling mechanisms and bone homeostasis. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2024 Insun Song et al.)
Databáze:	MEDLINE
Externí odkaz: