PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer.

Autor: Azad A; Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Institute of Genomic and Cancer Sciences, Vincent Drive, University of Birmingham, Birmingham, UK.; Comprehensive Cancer Centre, Kings' College London, London, UK., Arshad M; Institute of Genomic and Cancer Sciences, Vincent Drive, University of Birmingham, Birmingham, UK.; Comprehensive Cancer Centre, Kings' College London, London, UK., Generali D; U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy., Feldinger K; Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Gijsen M; Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Strina C; U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy., Cappelletti M; U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy., Andreis D; U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy.; Biostatistics and Clinical Trials Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRCCS, Forlì-Cesena, Meldola, Italy., Leek R; Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Haider S; Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; The Institute of Cancer Research, London, UK., Kellokumpu-Lehtinen PL; Department of Oncology, Tampere University Hospital and Tampere University, Tampere, Finland., Roxanis I; The Institute of Cancer Research, London, UK.; Department of Cellular Pathology, Oxford University Hospitals and Oxford Biomedical Research Centre, Oxford, UK., Harris AL; Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Shaaban AM; Department of histopathology, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Joensuu H; Department of Oncology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Kong A; Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Institute of Genomic and Cancer Sciences, Vincent Drive, University of Birmingham, Birmingham, UK.; Comprehensive Cancer Centre, Kings' College London, London, UK.
Jazyk: angličtina
Zdroj: Cancer communications (London, England) [Cancer Commun (Lond)] 2024 Nov 24. Date of Electronic Publication: 2024 Nov 24.
DOI: 10.1002/cac2.12632
Databáze: MEDLINE