Vaping and tumor metastasis: current insights and progress.

Autor: Xi Y; Department of Pathology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, 06510, USA., Yang L; Department of Pathology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, 06510, USA., Burtness B; Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06510, USA., Wang H; Department of Pathology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, 06510, USA. he.wang@yale.edu.
Jazyk: angličtina
Zdroj: Cancer metastasis reviews [Cancer Metastasis Rev] 2024 Nov 25; Vol. 44 (1), pp. 4. Date of Electronic Publication: 2024 Nov 25.
DOI: 10.1007/s10555-024-10221-7
Abstrakt: Tumor metastasis is the primary cause of cancer-related mortality and remains a major hurdle in cancer treatment. Traditional cigarette smoking has been extensively studied for its role in promoting metastasis. However, the impact of e-cigarette (e-cig) on cancer metastasis is not well understood despite their increasing popularity as a supposedly safer alternative. This mini review synthesizes current literature on the effects of e-cig on cancer metastasis, focusing on the processes of dissemination, dormancy, and colonization. It also incorporates recent findings from our laboratory regarding the role of e-cig in tumor progression. E-cig exposure enhances metastatic potential through various mechanisms: it induces epithelial-mesenchymal transition (EMT), increasing cell migratory and invasive capabilities; promotes lymphangiogenesis, aiding tumor cell spread; and alters the pre-metastatic niche to support dormant tumor cells, enhancing their reactivation and colonization. Furthermore, e-cig induce significant epigenetic changes, such as DNA methylation and histone modifications, which regulate genes involved in metastasis. Our data suggest that e-cig upregulate histone demethylases like KDM6B in macrophages, impacting the TME and promoting metastasis. These findings underscore the need for further research to understand the long-term health implications of e-cig use and inform public health policies to reduce e-cig use.
Competing Interests: Declarations. Ethical approval: Not applicable. Consent to participate: Not applicable. Conflict of interest: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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