Prospective cohort study exploring the neurodevelopmental outcomes following documented neonatal sepsis in Nepal: study protocol.

Autor:	Vaidya S; Health Science Research, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India., Raj M; Paediatrics & Paediatric Cardiology, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India drmanuraj@gmail.com., Sudevan R; Health Sciences Research, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India., Chandramathi J; Division of Neonatology, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India., Karmacharya SB; Neonatology, Paropakar Maternity and Women's Hospital, Kathmandu, Nepal., Subedi K; Neonatology, Paropakar Maternity and Women's Hospital, Kathmandu, Nepal., Raya GB; Paediatrics, Siddhi Memorial Foundation, Bhaktapur, Bagmati, Nepal., Shrestha D; Paediatrics, Siddhi Memorial Foundation, Bhaktapur, Bagmati, Nepal.
Jazyk:	angličtina
Zdroj:	BMJ paediatrics open [BMJ Paediatr Open] 2024 Nov 24; Vol. 8 (1). Date of Electronic Publication: 2024 Nov 24.
DOI:	10.1136/bmjpo-2024-002955
Abstrakt:	Introduction: Neonatal sepsis, a significant contributor to global neonatal mortality, poses substantial risks to infant health, particularly in low-resource countries like Nepal. Despite its high prevalence, there is a lack of clarity in defining and understanding neonatal sepsis, leading to challenges in diagnosing and managing the condition effectively. The probable impact of neonatal sepsis on long-term neurodevelopmental outcomes, including motor and cognitive delays, remains under-explored in Nepal. The primary objective of this study is to report the prevalence of neurodevelopmental delay in neonates with documented sepsis. The secondary objective is to report significant associations of the same with selected probable risk factors. Methods and Analysis: This is a dual-centric prospective cohort study that is ongoing at two hospitals-Paropakar Maternity and Women's Hospital and Siddhi Memorial Hospital in Nepal, over a 2-year period. Neonates diagnosed with sepsis will be assessed using the Developmental Assessment Scale for Indian Infants at 6 months and 1 year, postdiagnosis. Statistical analyses will include prevalence estimation and logistic regression. Competing Interests: Competing interests: The authors declare no competing interests regarding the publication of this study protocol exploring the neurodevelopmental outcomes following documented neonatal sepsis in Nepal. There are no financial or non-financial interests that could be perceived as potentially influencing the objectivity, integrity or validity of the research conducted or the conclusions drawn from it. All authors involved in the development of this protocol have no affiliations or involvement with any organisations or entities that have a direct or indirect interest in the subject matter discussed in this study. The research is conducted with the sole purpose of advancing knowledge and understanding neonatal sepsis and its impact on neurodevelopmental outcomes, without any external influences or conflicts of interest. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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