Galectins and Host-Pathogen Interactions: The roles in viral infections.

Autor: Wang SF; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Center for Tropical Medicine and Infectious Disease Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. Electronic address: wasf1234@kmu.edu.tw., Chen HL; Master Program in Clinical Genomics and Proteomics, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan., Liu FT; Department of Dermatology, Keck School of Medicine of USC, Los Angeles, CA 90033, USA; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan. Electronic address: ftliu@ibms.sinica.edu.tw.
Jazyk: angličtina
Zdroj: Seminars in immunology [Semin Immunol] 2024 Nov; Vol. 76, pp. 101911. Date of Electronic Publication: 2024 Nov 23.
DOI: 10.1016/j.smim.2024.101911
Abstrakt: Galectins, a family of carbohydrate-binding proteins, play crucial roles in the host-virus interaction landscape. This review explores the multifaceted contributions of endogenous galectins to various stages of the viral lifecycle, including attachment, replication, assembly, and release of progeny virions. Recent studies have indicated that viral infections can induce the expression and secretion of specific galectins, with elucidated signaling pathways in some cases, enhancing our understanding of their regulatory mechanisms. While many studies have focused on the effects of exogenous recombinant galectins, there is growing interest in the intrinsic functions of endogenous galectins, particularly through genetic alterations in cellular models. This review highlights the need for further research to uncover the complex roles of galectins in modulating viral infections and emphasizes their potential as therapeutic targets in the fight against viral diseases. Understanding these interactions could pave the way for novel strategies to enhance host defense mechanisms and mitigate viral pathogenesis.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: