Diet quality, body weight, and postmenopausal hot flashes: a secondary analysis of a randomized clinical trial.

Autor: Brennan H; Physicians Committee for Responsible Medicine, 5100 Wisconsin Ave, NW, Suite 400, Washington, DC, 20016, USA., Znayenko-Miller T; Physicians Committee for Responsible Medicine, 5100 Wisconsin Ave, NW, Suite 400, Washington, DC, 20016, USA., Sutton M; Physicians Committee for Responsible Medicine, 5100 Wisconsin Ave, NW, Suite 400, Washington, DC, 20016, USA., Holubkov R; School of Medicine, University of Utah, Salt Lake City, UT, USA., Barnard ND; Physicians Committee for Responsible Medicine, 5100 Wisconsin Ave, NW, Suite 400, Washington, DC, 20016, USA.; Adjunct faculty, George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Kahleova H; Physicians Committee for Responsible Medicine, 5100 Wisconsin Ave, NW, Suite 400, Washington, DC, 20016, USA. hkahleova@pcrm.org.
Jazyk: angličtina
Zdroj: BMC women's health [BMC Womens Health] 2024 Nov 23; Vol. 24 (1), pp. 620. Date of Electronic Publication: 2024 Nov 23.
DOI: 10.1186/s12905-024-03467-4
Abstrakt: Background: A low-fat vegan diet, supplemented with soybeans, has been shown effective in reducing postmenopausal hot flashes. This secondary analysis assessed the association of a plant-based index (PDI), healthful (hPDI), and unhealthful (uPDI), with changes in hot flashes in postmenopausal women.
Methods: Participants (n = 84) were randomly assigned to a low-fat vegan diet supplemented with soybeans (n = 42) or a control group (n = 42) for 12 weeks. Three-day dietary records were analyzed and PDI indices were calculated. A repeated measures analysis of variance (ANOVA) was used for statistical analysis.
Results: All three scores increased in the vegan group, compared with no change in the control group; the effect sizes were: PDI + 9.8 (95% CI + 5.8 to + 13.8; p < 0.001); hPDI + 10.9 (95% CI + 6.4 to + 15.3; p < 0.001); and uPDI + 3.6 (95% CI + 0.5 to + 6.6; p = 0.02). The change in all three scores negatively correlated with change in body weight (PDI: r=-0.48; p < 0.001; hPDI: r=-0.38; p = 0.002; and uPDI: r=-0.31; p = 0.01). The changes in PDI and uPDI were negatively associated with changes in severe hot flashes (r=-0.34; p = 0.009; and r=-0.43; p < 0.001, respectively), and associations remained significant after adjustment for changes in body mass index (r=-0.31; p = 0.02; and r=-0.41; p = 0.001, respectively).
Conclusions: These findings suggest that minimizing the consumption of animal products and oil may be an effective strategy to reduce hot flashes in postmenopausal women, and that categorization of plant foods as "healthful" or "unhealthful" may be unwarranted.
Trial Registration: ClinicalTrials.gov, NCT04587154, registered on Oct 14, 2020.
Competing Interests: Declarations. Human Ethics and Consent to participate: The study was performed in accordance with the Declaration of Helsinki. The Advarra Institutional Review Board approved the study on September 2, 2020 (Pro00045315). All participants provided written informed consent. This study follows the Consolidated Standards of Reporting Trials (CONSORT) reporting guidelines. Consent for publication: Not Applicable. Competing interests: Dr. Kahleova, Ms. Brennan, Ms. Znayenko-Miller, Ms. Sutton, and Dr. Holubkov received compensation from the Physicians Committee for Responsible Medicine for their work on this study. Dr. Barnard is an Adjunct Professor of Medicine at the George Washington University School of Medicine. He serves without compensation as president of the Physicians Committee for Responsible Medicine and Barnard Medical Center in Washington, DC, nonprofit organizations providing educational, research, and medical services related to nutrition. He writes books and articles and gives lectures related to nutrition and health and has received royalties and honoraria from these sources.
(© 2024. The Author(s).)
Databáze: MEDLINE
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