Imaging findings in a case of primary intraosseous carcinoma arising from a mandibular cyst.

Autor: Kami Y; Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. kami@rad.dent.kyushu-u.ac.jp., Chikui T; Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Fujii S; Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.; Dento-Craniofacial Development and Regeneration Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan., Fujimoto T; Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.; Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan., Kumamaru W; Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan., Hasegawa K; Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan., Nakamatsu K; Department of Dentistry and Oral Surgery, Iizuka Hospital, Fukuoka, Japan., Okamura K; Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Yasaka M; Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Kiyoshima T; Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan., Yoshiura K; Fukuoka, Japan.
Jazyk: angličtina
Zdroj: Oral radiology [Oral Radiol] 2024 Nov 23. Date of Electronic Publication: 2024 Nov 23.
DOI: 10.1007/s11282-024-00788-w
Abstrakt: Primary intraosseous carcinoma not otherwise specified (PIOC NOS) is a rare tumor assumed to arise from the epithelium, such as odontogenic cysts or benign tumors. Its clinical and imaging diagnoses are often challenging, especially in the early stages, as it mimics jaw cysts and benign tumors, and no specific findings have been identified. This report presents the case of a 66-year-old male patient with mandibular PIOC, highlighting the imaging findings over time. Magnetic resonance imaging (MRI) before symptom onset showed a cystic lesion in the right mandible with a soft tissue component. Both the fluid component and soft tissue exhibited low apparent diffusion coefficient values (1.0 × 10 -3 mm 2 /s and 1.3 × 10 -3 mm 2 /s, respectively). Subsequent MRI approximately 5 months later during symptom onset showed a slight increase in the soft tissue component. Based on the clinical and imaging findings, ameloblastoma was suspected, prompting a biopsy for confirmation. However, the histopathological findings showed squamous cell carcinoma (SCC). MRI performed approximately 1 month later exhibited significant tumor growth and extension beyond the jawbone, consistent with a malignant tumor. Histopathological examination identified areas with a basal layer in a palisading arrangement, indicating a pre-existing odontogenic cyst, and showed a transition from epithelial dysplasia to SCC. In addition, carcinoma cell invasion and proliferation into the cyst were observed. Based on these findings, PIOC of the right mandible was determined to be the definitive diagnosis.
Competing Interests: Declarations. Conflict of interest: All authors declare that they have no conflict of interest. Ethical approval: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). At our institution, ethical review is waived for case reports, although informed consent must be obtained from the patient. Informed consent: Informed consent was obtained from the patient for being included in the study.
(© 2024. The Author(s) under exclusive licence to Japanese Society for Oral and Maxillofacial Radiology.)
Databáze: MEDLINE
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