| Autor: |
Yu SH; Department of Food Regulatory Science, Korea University, Sejong, Republic of Korea.; Univera Co., Ltd., Cheonan, Republic of Korea., Oh HR; Department of Food Regulatory Science, Korea University, Sejong, Republic of Korea.; Naturetech, Jingcheon, Republic of Korea., Park YH; Department of Food Regulatory Science, Korea University, Sejong, Republic of Korea.; Naturetech, Jingcheon, Republic of Korea., Hong HR; Naturetech, Jingcheon, Republic of Korea., Kim HJ; Department of Food Regulatory Science, Korea University, Sejong, Republic of Korea.; Naturetech, Jingcheon, Republic of Korea., Park J; Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea., Han Y; Department of Microbiology, Wonkwang University School of Medicine, Iksan, Republic of Korea., Ko SG; Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea., Shin EC; Department of GreenBio Science, Gyeongsang National University, Jinju, Republic of Korea., Kim TG; The Bioinformatix, Gwangmyeong, Republic of Korea., Cho HT; The Bioinformatix, Gwangmyeong, Republic of Korea., Pan JH; Department of Food and Nutrition, Chosun University, Gwangju, Republic of Korea.; The Basic Science Institute of Chosun University, Gwangju, Republic of Korea., Shim YY; Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea.; Department of Food and Bioproduct Sciences, University of Saskatchewan, Saskatoon, Canada., Reaney MJT; Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea.; Department of Food and Bioproduct Sciences, University of Saskatchewan, Saskatoon, Canada., Cho TJ; Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea., Hong JY; Department of Food Regulatory Science, Korea University, Sejong, Republic of Korea.; Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea., Kim YJ; Department of Food Regulatory Science, Korea University, Sejong, Republic of Korea.; Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea., Han BK; Department of Food Regulatory Science, Korea University, Sejong, Republic of Korea.; Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea., Lee GJ; Department of Horticulture, Chungnam National University, Daejeon, Republic of Korea., Lee K; Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea., Do SG; Naturetech, Jingcheon, Republic of Korea., Kim JK; Department of Food and Biotechnology, Korea University, Sejong, Republic of Korea.; Department of Behavioral Health and Nutrition, University of Delaware, Newark, Delaware, USA. |
| Abstrakt: |
Ginsenosides, active compounds derived from Panax ginseng, exhibit promising potential in enhancing physical performance. This study investigates the impact of UG0712 (UG), a novel ginsenoside compound, on endurance capacity, body weight, organ weights, blood parameters, and specific transcriptomic changes in liver and muscle tissues using a C57BL/6N mouse model. The mice received UGs orally at three doses: UG50 (50 mg/kg), UG100 (100 mg/kg), and UG200 (200 mg/kg) for a specified duration. Endurance capacity, physiological parameters, and transcriptome signatures in liver and muscle tissues were assessed. UG administration significantly improved time to exhaustion, with UG50 and UG200 showing substantial enhancements. Body and organ weights exhibited no notable differences, suggesting a lack of adverse effects. Biochemical markers, except for decreased creatine kinase levels in the UG100 group, showed no significant variations. Transcriptome analysis revealed limited group separation and dose-dependent patterns. The UG100 group displayed significant enrichment in lipid metabolism and muscle-related terms. Identified dose-dependent improvements in endurance capacity highlight UGs' potential as supplements. The absence of adverse effects on body and organ weights, along with positive effects on biochemical markers, supports their safety. Despite limited dose-dependent patterns in transcriptomic analyses, the UG100 group showcased significant enrichment in pathways related to muscle and lipid metabolism. These findings offer valuable insights for athletes and aging individuals seeking to enhance physical performance, warranting further exploration into UG effects' on molecular mechanisms. |
