Role of leptin and Insulin like growth Factor-1 In regulation of growth in children with congenital cyanotic heart disease.
| Autor: | Elsharkawy AA; Department of pediatrics, Mansoura University, Mansoura, Egypt., El-Hawary AK; Department of pediatrics, Mansoura University, Mansoura, Egypt., AlSawah GA; Department of pediatrics, Mansoura University, Mansoura, Egypt., AboElenin HM; Department of pediatrics, Mansoura University, Mansoura, Egypt., Awad MH; Department of pediatrics, Mansoura University, Mansoura, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | Growth factors (Chur, Switzerland) [Growth Factors] 2024 Nov 23, pp. 1-7. Date of Electronic Publication: 2024 Nov 23. |
| DOI: | 10.1080/08977194.2024.2432941 |
| Abstrakt: | Background: Congenital cyanotic heart disease (CHD) in children is associated with several complications, amongst these complications is growth retardation which is believed to be multifactorial. Objectives: The objective of this study is to find out the role of leptin and Insulin-Like Growth Factor-1 (IGF-1) in the growth of paediatric patients with cyanotic CHD of different anatomical defects. Design/methods: This is a cross-sectional study involving thirty-nine children known to suffer from congenital cyanotic heart disease followed by the cardiology outpatient department, and forty-seven matched controls. Serum leptin and IGF-1 were evaluated in all the enrolled subjects besides anthropometric measurement and assessment of average oxygen saturation. Results: The patients' group showed statistically significant lower height, weight, Body mass index (BMI), leptin levels, and IGF-1. In addition, the patient group had a significant positive correlation between serum leptin and BMI, as well as a positive correlation of IGF-1 with average oxygen saturation. Conclusion: Children suffering from congenital cyanotic heart disease have a higher probability of developing poor growth. Serum leptin and IGF-1 are lower in affected children with congenital cyanotic cardiac defects suggesting that they may play a role in their poor growth. |
| Databáze: | MEDLINE |
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