Effect of chronic exogenous oxytocin administration on exercise performance and cardiovagal control in hypobaric hypoxia in rats.

Autor: Salazar-Ardiles C; Exercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta, Chile.; Navarrabiomed, Hospital Universitario de Navarra (UHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Navarra, Spain., Cornejo C; Exercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta, Chile., Paz C; Exercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta, Chile., Vasquez-Muñoz M; Dirección de Docencia de Especialidades Médicas, Dirección de Postgrado, Facultad de Medicina y Ciencias de la Salud, Universidad Mayor, Santiago, Chile., Arce-Alvarez A; Escuela de Kinesiología, Facultad de Odontología y Ciencias de la Rehabilitación, Universidad San Sebastian, Santiago, Chile., Rodriguez-Fernandez M; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine, and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile., Millet GP; Institute of Sport Sciences, University of Lausanne, Lausanne, CH-1015, Switzerland., Izquierdo M; Navarrabiomed, Hospital Universitario de Navarra (UHN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Navarra, Spain., Andrade DC; Exercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta, Chile. david.andrade@uantof.cl.
Jazyk: angličtina
Zdroj: Biological research [Biol Res] 2024 Nov 23; Vol. 57 (1), pp. 88. Date of Electronic Publication: 2024 Nov 23.
DOI: 10.1186/s40659-024-00573-3
Abstrakt: Background: Outstanding exercise performance has been associated with an exacerbated vagal outflow. Nevertheless, during high-altitude hypobaric-hypoxia (HH), there is a baroreflex-dependent parasympathetic withdrawal and exercise performance deterioration. Notably, vagal control is pivotal in exercise performance, and exogenous oxytocin (OXY) administration has been shown to enhance parasympathetic drive; however, no evidence shows their role in exercise performance during HH. Then, this study aimed to examine the effect of prolonged exogenous oxytocin (OXY) administration on exercise performance during hypobaric hypoxia (HH) in rats.
Results: A vehicle group (n = 6) and an OXY group (n = 6) performed incremental exercise and baroreflex tests during both normobaric normoxia (NN) and HH (PO 2 : 100 mmHg, simulated 3,500 m) prior (pre-) and after (post-) 14 days of administration. The results showed that at pre-, there were no significant differences in exercise performance between the two groups, while at post-, the OXY group exhibited similar performance between NN and HH, while the Vehicle group maintained a significant decline in performance at HH compared to NN. At post-, the Vehicle group also demonstrated a reset in the baroreflex and a worse bradycardic response in HH, which was reversed in the OXY group, while the hypoxic ventilatory response was similar in both groups.
Conclusion: The findings suggest prolonged OXY administration prevents impaired exercise performance and vagal control during short-term HH.
Competing Interests: Declarations. Ethics approval and consent to participate: Animal welfare guidelines for this study were established by the American Physiological Society. The protocols were approved by the Ethics Committee on Scientific Research at the Universidad de Antofagasta (CEIC-UA 438/2022). Consent for publication: Not applicable. Competing interests: The authors declare that this study received funding from Minera Escondida Ltda. The funder was not involved in the study design, data collection, analysis, interpretation, writing of this article, or the decision to submit it for publication.
(© 2024. The Author(s).)
Databáze: MEDLINE
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