The role of interleukin-20 on inflammatory stress and periodontal tissue destruction in patients with metabolic syndrome and periodontitis.

Autor: Senkal R; Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdoğan University, Rize, 53100, Turkey., Yemenoglu H; Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdoğan University, Rize, 53100, Turkey. htcymnglu@hotmail.com., Kose O; Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdoğan University, Rize, 53100, Turkey., Karakas SM; Department of Biochemistry, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey., Yilmaz A; Department of Biochemistry, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey., Akyildiz K; Department of Medical Services and Techniques, Health Care Services Vocational School, Recep Tayyip Erdoğan University, Rize, Turkey., Beder M; Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdoğan University, Rize, 53100, Turkey., Bostan SA; Department of Periodontology, Faculty of Dentistry, Recep Tayyip Erdoğan University, Rize, 53100, Turkey.
Jazyk: angličtina
Zdroj: BMC oral health [BMC Oral Health] 2024 Nov 22; Vol. 24 (1), pp. 1423. Date of Electronic Publication: 2024 Nov 22.
DOI: 10.1186/s12903-024-05224-3
Abstrakt: Background: There is an increasing occurrence of periodontitis and metabolic syndrome (MetS), which is resulting in a decline in the overall quality of life. Both disorders can occur together since they are both linked to insulin resistance and systemic inflammation. However, evidence for a role of interleukin (IL)-20 in this comorbidity is very limited. This cross-sectional study aimed to comprehensively investigate, for the first time, the levels of RANKL/OPG, MMP-8 and OSI as well as the role of IL-20 in patients with MetS and periodontitis.
Methods: The study included a total of 80 individuals, divided into four groups: 20 individuals who were healthy both systemically and periodontally, 20 individuals who were systemically healthy but had periodontitis, 20 individuals who had MetS but were periodontally healthy, and 20 individuals who had both MetS and periodontitis. Periodontal clinical parameters (plaque index, gingival index, bleeding on probing, clinical attachment loss, probing pocket depth) were evaluated. Gingival crevicular fluid (GGF) and serum samples were collected and used for biochemical assays. Enzyme-linked immunosorbent assay was used to determine the levels of IL-20, receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG), matrix metalloproteinase-8 (MMP-8) and oxidative stress index (OSI).
Results: IL-20 levels measured in serum and GCF were statistically significantly highest in patients with MetS and periodontitis (p = 0.001). Significant positive correlation was observed between serum and GCF IL-20 values and periodontal parameters (p < 0.05). There was a positive correlation between RANKL and RANKL/OPG levels and IL-20 and clinical parameters (p < 0.05). OSI values were found to be increased in the presence of both periodontitis and MetS (p = 0.001) and were positively correlated with serum and GCF IL-20 (p < 0.05).
Conclusions: These data from the study suggest a correlation between IL-20 and both MetS and periodontitis. IL-20 may potentially worsen the condition of periodontal tissue by increasing both the oxidative stress levels, periodontal collagen degredation and the ratio of RANKL to OPG.
Trial Registration: This study was registered on ClinicTrials.gov (NCT06092853), 2023-10-10, retrospectively registered.
Competing Interests: Declarations. Human ethics and constent to participate: Ethical approval was obtained from the Non-Invasive Clinical Research Ethics Committee of Recep Tayyip Erdoğan University (Decision no: 2022/27). The study was conducted in accordance with the Declaration of Helsinki of 1975, as revised in 2013. The purpose and content of the research were explained to all individuals included in the study and voluntary consent forms were signed. Constent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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