Female Reproductive Period Length, Parity and Hormonal Replacement Therapy and Dementia: The Elsi-Brazil Study.

Autor: Barbosa MG; Psychogeriatric Unit, Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil., Keinert AÁM; Psychogeriatric Unit, Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil., Miguel ACC; Psychogeriatric Unit, Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.; Institute of Psychiatry, Universidade de São Paulo, São Paulo, Brazil., Macêdo MACF; Psychogeriatric Unit, Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil., Teixeira LM; Psychogeriatric Unit, Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil., Bertola L; Psychogeriatric Unit, Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.; Health Technology Assessment Unit, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil., Lima-Costa MF; Fundação Oswaldo Cruz, René Rachou Research Institute, Belo Horizonte, Brazil.; Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Ferri CP; Psychogeriatric Unit, Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.; Health Technology Assessment Unit, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: International journal of geriatric psychiatry [Int J Geriatr Psychiatry] 2024 Nov; Vol. 39 (11), pp. e70023.
DOI: 10.1002/gps.70023
Abstrakt: Introduction: Alzheimer's disease and other dementia have a higher incidence among women and that risk factors specific to the female sex could be involved. Few studies looked into female reproductive factors and their association with dementia in low-and middle-income countries.
Materials and Methods: We analyzed the baseline data from the Brazilian Longitudinal Study of Aging (ELSI-Brazil) and included data from 2594 women aged 60 years and older. We used an algorithm approach to determine dementia status and performed logistic regressions using as predictors the self-reported total length of the reproductive period, total parity and use of hormonal replacement therapy. We also analyzed the effects of hormonal replacement therapy use for different age groups and the effects of number of living children.
Results: Reproductive period length, hormonal replacement therapy use and parity as a continuous measure were not significantly associated with dementia status. When compared with 0 births, the group with 5-8 had more dementia while the other groups displayed no differences. For the number of living children, but a higher occurrence of dementia was found among women with more children.
Conclusions: We did not find any association between continuous parity, reproductive period length or hormonal replacement therapy use and dementia. Social factors of motherhood appear to play an important role, and group specific effects of parity and hormonal replacement therapy require further study.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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