Impact of body fat composition on liver iron overload severity in hemochromatosis: a retrospective MRI analysis.

Autor: Pušeljić M; Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036, Graz, Austria., Stadlbauer V; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.; Center of Biomarker Research in Medicine (CBmed), Stiftingtalstrasse 5, 8010, Graz, Austria., Ahmadova N; Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036, Graz, Austria., Pohl M; Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036, Graz, Austria., Kopetzky M; Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036, Graz, Austria., Kaufmann-Bühler AK; Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036, Graz, Austria., Watzinger N; Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036, Graz, Austria., Igrec J; Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036, Graz, Austria., Fuchsjäger M; Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036, Graz, Austria., Talakić E; Division of General Radiology, Department of Radiology, Medical University of Graz, Auenbruggerplatz 9, 8036, Graz, Austria. emina.talakic@medunigraz.at.
Jazyk: angličtina
Zdroj: La Radiologia medica [Radiol Med] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.
DOI: 10.1007/s11547-024-01930-8
Abstrakt: Purpose: To evaluate the correlation between ectopic adipose tissue and iron overload severity in patients with hemochromatosis.
Material and Methods: A retrospective cohort of 52 patients who underwent liver iron concentration quantification from January 2015 to October 2023 using a 3.0T MRI scanner. R2* relaxation times and proton density fat fraction (PDFF) were assessed for the entire liver volume and a specific region of interest (ROI) placed in the right lobe. Total body fat (TF), subcutaneous fat (SCF), intermuscular fat (IMF), and visceral fat (VSF) percentages were calculated from a single axial slice at the level of the third lumbar vertebra. Additionally, ratios of IMF-to-VSF, IMF-to-SCF, and SCF-to-VSF were calculated. Standard iron laboratory parameters were collected at least one month prior to MRI. Pearson correlation coefficient was used for correlation analysis.
Results: The mean age of participants was 53.9 ± 19.6 years. IMF positively correlated with R2* values in the ROI (p = 0.005, r s  = 0.382) and entire liver (p = 0.016, r s  = 0.332). Conversely, VSF negatively correlated with R2* values from the ROI (p = < 0.001, r s  = - 0.488) and entire liver (p = < 0.001, r s  = - 0.459). Positive correlations were also found between IMF-to-VSF and R2* of the ROI (p = 0.003, r s  = 0.400) and whole liver (p = 0.008, r s  = 0.364). Ferritin levels positively correlated with R2* values calculated from ROI (p = 0.002, r s  = 0.417) and whole liver volume (p = 0.004, r s  = 0.397). A positive correlation was noted between PDFF of the entire liver and TF (p = 0.024, rs = 0.313).
Conclusion: The percentage of Intermuscular and visceral adipose tissues correlates with the severity of liver iron overload in hemochromatosis patients.
Competing Interests: Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of University of Graz (31.10.2023 / EK-Number 35-346 ex 22/23). The need for written informed consent was waived.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: