Determinants of antimicrobial resistance in biosolids: A systematic review, database, and meta-analysis.

Autor: Harrison JC; The Biodesign Institute Center for Environmental Health Engineering, Arizona State University, 1001 S. McAllister Ave, Tempe, AZ 85281, USA; School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85281, USA., Morgan GV; The Biodesign Institute Center for Environmental Health Engineering, Arizona State University, 1001 S. McAllister Ave, Tempe, AZ 85281, USA., Kuppravalli A; The Biodesign Institute Center for Environmental Health Engineering, Arizona State University, 1001 S. McAllister Ave, Tempe, AZ 85281, USA; School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85281, USA., Novak N; Wilson Engineers, Tempe, AZ 85282, USA., Farrell M; The Biodesign Institute Center for Environmental Health Engineering, Arizona State University, 1001 S. McAllister Ave, Tempe, AZ 85281, USA; School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85281, USA., Bircher S; Wadsworth Department of Civil and Environmental Engineering, West Virginia University, Morgantown, WV 26505, USA., Garner E; Wadsworth Department of Civil and Environmental Engineering, West Virginia University, Morgantown, WV 26505, USA., Ashbolt NJ; Cooperative Research Centre for Solving Antimicrobial Resistance in Agribusiness, Food and Environments (CRC SAAFE), Mawson Lakes, SA 5095, Australia., Pruden A; Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA 24061, USA., Muenich RL; Biological and Agricultural Engineering, University of Arkansas, 790 W. Dickson St., Fayetteville, AR 72701, USA., Boyer TH; School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85281, USA., Williams C; US Department of Agriculture Arid Land Agricultural Research Center, Maricopa, AZ, USA., Ahmed W; CSIRO Environment, Ecosciences Precinct, 41 Boggo Road, Dutton Park, QLD 4102, Australia., Maal-Bared R; Bellevue Research and Testing Laboratory, CDM Smith, 14432 SE Eastgate Way Suite 100, Bellevue, WA 98007, USA., Hamilton KA; The Biodesign Institute Center for Environmental Health Engineering, Arizona State University, 1001 S. McAllister Ave, Tempe, AZ 85281, USA; School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85281, USA. Electronic address: kerry.hamilton@asu.edu.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Nov 27; Vol. 957, pp. 177455. Date of Electronic Publication: 2024 Nov 27.
DOI: 10.1016/j.scitotenv.2024.177455
Abstrakt: Biosolids can provide a nutrient rich soil amendment, particularly for poor soils and semi-arid or drought-prone areas. However, there are concerns that sludge and biosolids could be a source of propagation and exposure to AMR determinants such as antibiotic resistant bacteria (ARB), and antibiotic resistance genes (ARGs). To inform risk assessment efforts, a systematic literature review was performed to build a comprehensive spreadsheet database of ARB and ARG concentrations in biosolids (and some sludges specified as intended for land application), along with 69 other quantitative and qualitative meta-data fields from 68 published studies describing sampling information and processing methods that can be used for modeling purposes. Mean ARG concentrations per gram in positive samples of biosolids ranged from -5.7 log 10 (gene copies [gc]/g) to 12.92 log 10 (gc/g) (with these range values reported per dry weight), and aqueous concentrations ranged from 0.9 log 10 (gc/L) to 14.6 log 10 (gc/L). Mean ARB concentrations per gram of biosolids ranged from 2.02 log 10 (colony forming units [CFU]/g) to 9.00 log 10 (CFU/g) (dry weight), and aqueous concentrations ranged from 3.23 log 10 (CFU/L) to 12.0 log 10 (CFU/L). ARG log removal values (LRVs) during sewage sludge stabilization were calculated from a meta-analysis of mean concentrations before and after stabilization from 31 studies, ranging from -2.05 to 5.52 logs. The classes of resistance most relevant for a risk assessment corresponded to sulfonamide (sul1 and sul2), tetracycline (tetZ, tetX, tetA and tetG), beta-lactam (bla TEM ), macrolide (ermB and ermF), aminoglycoside (strA and aac(6')-Ib-cr), and integron-associated (intI1). The resistance classes most relevant for ARB risk assessment included sulfonamides (sulfamethoxazole and sulfamethazine), cephalosporin (cephalothin and cefoxitin), penicillin (ampicillin), and ciprofloxin (ciprofloxacin). Considerations for exposure assessment are discussed to highlight risk assessment needs relating to antimicrobial resistance (AMR) associated with biosolids application. This study aids in prioritization of resources for reducing the spread of AMR within a One Health framework.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kerry Hamilton reports financial support was provided by Water Research Foundation. Kerry Hamilton reports financial support was provided by U.S. Department of Agriculture. Nicholas Ashbolt reports administrative support was provided by The Cooperative Research Centre for Solving Antimicrobial Resistance in Agribusiness, Food and Environments (CRC SAAFE). If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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