Response of platelet count in the US population following exposure to BDEs and BB: A cross-sectional analysis of database of NHANES (2007-2016).

Autor: Huang SS; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315100, China., Ding Y; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315100, China., Mao HY; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315100, China., Jin SF; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315100, China., Zheng MX; Department of Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315100, China., Yang ZX; Zhejiang Key Laboratory of Geriatrics and Geriatrics Institute of Zhejiang Province, Zhejiang Hospital, Hangzhou 310030, China. Electronic address: yangzhouxin@hotmail.com.
Jazyk: angličtina
Zdroj: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2024 Dec; Vol. 288, pp. 117384. Date of Electronic Publication: 2024 Nov 21.
DOI: 10.1016/j.ecoenv.2024.117384
Abstrakt: Brominated flame retardants (BFRs) are environmental pollutants linked to health risks, including increased platelet (PLT) levels that may elevate the risk of thrombosis and cardiovascular diseases. This study examined the association between BFR exposure and PLT levels among 5831 adult participants from the National Health and Nutrition Examination Survey (NHANES) (2007-2016). Of the 12 BFRs analyzed, BB153, BDE17, BDE85, BDE154, BDE183, and BDE209 showed significant positive correlations with PLT levels (p < 0.05), with BDE17 demonstrating the strongest correlation (Spearman's coefficient = 0.122). After adjusting for confounders, all BFRs except BDE153 remained significantly associated with elevated PLT levels. Restricted cubic spline analysis indicated varying associations, with BDE99, BDE183, and BDE209 showing an "S"-shaped relationship, while BB153, BDE17, and BDE66 presented an inverted "J"-shaped relationship. BDE153 exhibited a "U"-shaped relationship with PLT level. Both weighted quantile sum regression and quantile-based g-computation confirmed that BFR mixtures positively correlated with PLT levels, with BDE17 as the most significant contributor. Our findings suggest that BFR exposure is associated with increased PLT levels, indicating a potential risk for thrombosis and related cardiovascular conditions.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Zhou-Xin Yang reports financial support was provided by Zhejiang Provincial Natural Science Foundation of China. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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