Distribution of group B streptococci serotypes on women nasopharynx.

Autor:	Pereira MDCA; Universidade Federal da Paraíba (UFPB), Centro de Ciências Médicas (CCM), Mestrado Profissional em Saúde da Família, João Pessoa, PB, Brazil., Hilário FF; Universidade Federal da Paraíba (UFPB), Centro de Ciências Médicas (CCM), Laboratório de Biologia Molecular (LaBiMoL), João Pessoa, PB, Brazil., Campana EH; Universidade Federal da Paraíba (UFPB), Centro de Ciências Médicas (CCM), Laboratório de Biologia Molecular (LaBiMoL), João Pessoa, PB, Brazil., Sousa ESS; Universidade Federal da Paraíba (UFPB), Centro de Ciências Médicas (CCM), Laboratório de Biologia Molecular (LaBiMoL), João Pessoa, PB, Brazil., Perez VP; Universidade Federal da Paraíba (UFPB), Centro de Ciências da Saúde (CCS), Núcleo de Medicina Tropical (NUMETROP), João Pessoa, PB, Brazil. Electronic address: vinicius.perez@academico.ufpb.br.
Jazyk:	angličtina
Zdroj:	The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2024 Nov-Dec; Vol. 28 (6), pp. 104469. Date of Electronic Publication: 2024 Nov 21.
DOI:	10.1016/j.bjid.2024.104469
Abstrakt:	Group B Streptococcus (GBS) is a significant pathogen responsible for neonatal infections, primarily transmitted through maternal carriage. However, current preventive strategies, such as intrapartum antibiotic prophylaxis, present limitations and are ineffective in preventing late-onset neonatal infections. This study aimed to assess the prevalence and serotype distribution of GBS in the nasopharynx of women of reproductive age, providing data to the potential implementation of a novel hexavalent capsular vaccine (GBS6). Nasopharyngeal swabs were collected from 500 women and analyzed using a qPCR assay targeting the cfb gene to detect GBS and the cps locus. GBS was identified in 7.4 % of patients, with serotype Ia being the most prevalent. Other serotypes detected included II, V, Ib, III, and IV. These findings suggest that the nasopharynx may act as a reservoir for GBS in women of reproductive age. The results also highlight the importance of developing preventive strategies focused on upper respiratory tract colonization. Additionally, the potential introduction of the GBS6 vaccine could provide significant coverage against circulating GBS serotypes. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2024. Published by Elsevier España, S.L.U.)
Databáze:	MEDLINE
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