Cardioprotective Effect of Selective μ 2 -Opioid Receptor Agonist Endomorphin-1 in Cardiac Reperfusion In Vivo and In Vitro.

Autor: Gorbunov AS; Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russia., Mukhomedzyanov AV; Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russia. sasha_m91@mail.ru., Popov SV; Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russia., Azev VN; Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia., Maslov LN; Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Nov; Vol. 178 (1), pp. 86-90. Date of Electronic Publication: 2024 Nov 22.
DOI: 10.1007/s10517-024-06287-6
Abstrakt: The effect of the selective μ 2 -opioid receptor agonist endomorphin-1 in reperfusion injury in male Wistar rats was studied in vivo and in vitro. The in vivo experiment included coronary artery occlusion (45 min) and reperfusion (120 min); in in vitro experiments, 45-min global ischemia of the isolated rat heart was followed by 30-min reperfusion. Endomorphin-1 was administered intravenously 5 min before in vivo reperfusion (at a dose 50 μg/kg) or added to the perfusion solution at the onset of reperfusion of the isolated heart (in a concentration of 152 nmol/liter). In vivo endomorphin-1 reduced the infarct size by 33% compared to the control group. In experiments on isolated heart, endomorphin-1 improved the contractile function during reperfusion and reduced the creatine kinase level in the coronary effluent. Hence, stimulation of cardiac μ 2 -opioid receptors increases heart tolerance to the pathogenic effects of reperfusion.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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